Human mini-blood–brain barrier models for biomedical neuroscience research: a review
Abstract The human blood–brain barrier (BBB) is a unique multicellular structure that is in critical demand for fundamental neuroscience studies and therapeutic evaluation. Despite substantial achievements in creating in vitro human BBB platforms, challenges in generating specifics of physiopatholog...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2022-12-01
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| Series: | Biomaterials Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40824-022-00332-z |
| _version_ | 1797285731158196224 |
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| author | Minh Tran Chaejeong Heo Luke P. Lee Hansang Cho |
| author_facet | Minh Tran Chaejeong Heo Luke P. Lee Hansang Cho |
| author_sort | Minh Tran |
| collection | DOAJ |
| description | Abstract The human blood–brain barrier (BBB) is a unique multicellular structure that is in critical demand for fundamental neuroscience studies and therapeutic evaluation. Despite substantial achievements in creating in vitro human BBB platforms, challenges in generating specifics of physiopathological relevance are viewed as impediments to the establishment of in vitro models. In this review, we provide insight into the development and deployment of in vitro BBB models that allow investigation of the physiology and pathology of neurological therapeutic avenues. First, we highlight the critical components, including cell sources, biomaterial glue collections, and engineering techniques to reconstruct a miniaturized human BBB. Second, we describe recent breakthroughs in human mini-BBBs for investigating biological mechanisms in neurology. Finally, we discuss the application of human mini-BBBs to medical approaches. This review provides strategies for understanding neurological diseases, a validation model for drug discovery, and a potential approach for generating personalized medicine. |
| first_indexed | 2024-03-07T18:07:28Z |
| format | Article |
| id | doaj.art-635ecb8e1fb8455ea21ff2fb464e78f5 |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T18:07:28Z |
| publishDate | 2022-12-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-635ecb8e1fb8455ea21ff2fb464e78f52024-03-02T08:35:36ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242022-12-0126112010.1186/s40824-022-00332-zHuman mini-blood–brain barrier models for biomedical neuroscience research: a reviewMinh Tran0Chaejeong Heo1Luke P. Lee2Hansang Cho3Institute of Quantum Biophysics, Sungkyunkwan UniversityInstitute of Quantum Biophysics, Sungkyunkwan UniversityInstitute of Quantum Biophysics, Sungkyunkwan UniversityInstitute of Quantum Biophysics, Sungkyunkwan UniversityAbstract The human blood–brain barrier (BBB) is a unique multicellular structure that is in critical demand for fundamental neuroscience studies and therapeutic evaluation. Despite substantial achievements in creating in vitro human BBB platforms, challenges in generating specifics of physiopathological relevance are viewed as impediments to the establishment of in vitro models. In this review, we provide insight into the development and deployment of in vitro BBB models that allow investigation of the physiology and pathology of neurological therapeutic avenues. First, we highlight the critical components, including cell sources, biomaterial glue collections, and engineering techniques to reconstruct a miniaturized human BBB. Second, we describe recent breakthroughs in human mini-BBBs for investigating biological mechanisms in neurology. Finally, we discuss the application of human mini-BBBs to medical approaches. This review provides strategies for understanding neurological diseases, a validation model for drug discovery, and a potential approach for generating personalized medicine.https://doi.org/10.1186/s40824-022-00332-zBlood–brain barrierHuman mini-brainsNeurological disorderPersonalized medicine |
| spellingShingle | Minh Tran Chaejeong Heo Luke P. Lee Hansang Cho Human mini-blood–brain barrier models for biomedical neuroscience research: a review Biomaterials Research Blood–brain barrier Human mini-brains Neurological disorder Personalized medicine |
| title | Human mini-blood–brain barrier models for biomedical neuroscience research: a review |
| title_full | Human mini-blood–brain barrier models for biomedical neuroscience research: a review |
| title_fullStr | Human mini-blood–brain barrier models for biomedical neuroscience research: a review |
| title_full_unstemmed | Human mini-blood–brain barrier models for biomedical neuroscience research: a review |
| title_short | Human mini-blood–brain barrier models for biomedical neuroscience research: a review |
| title_sort | human mini blood brain barrier models for biomedical neuroscience research a review |
| topic | Blood–brain barrier Human mini-brains Neurological disorder Personalized medicine |
| url | https://doi.org/10.1186/s40824-022-00332-z |
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