Retrospective cohort study of the risk of impaired glucose tolerance among shift workers
OBJECTIVES: The aim of this study was to investigate the effect of shift working on the risk of developing impaired glucose tolerance (IGT). METHODS: This study comprised 6413 male employees (5608 daytime workers, 512 3-shift workers and 293 2-shift workers) whose work schedules remained constant du...
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| Format: | Article |
| Language: | English |
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Nordic Association of Occupational Safety and Health (NOROSH)
2012-07-01
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| Series: | Scandinavian Journal of Work, Environment & Health |
| Subjects: | |
| Online Access: |
https://www.sjweh.fi/show_abstract.php?abstract_id=3297
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| _version_ | 1818915753090351104 |
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| author | Ichiro Oyama Tomohide Kubo Yoshihisa Fujino Koji Kadowaki Masamizu Kunimoto Kiyoyumi Shirane Hidetoshi Tabata Ken Sabanai Takehiro Nakamura Shinya Matsuda |
| author_facet | Ichiro Oyama Tomohide Kubo Yoshihisa Fujino Koji Kadowaki Masamizu Kunimoto Kiyoyumi Shirane Hidetoshi Tabata Ken Sabanai Takehiro Nakamura Shinya Matsuda |
| author_sort | Ichiro Oyama |
| collection | DOAJ |
| description | OBJECTIVES: The aim of this study was to investigate the effect of shift working on the risk of developing impaired glucose tolerance (IGT). METHODS: This study comprised 6413 male employees (5608 daytime workers, 512 3-shift workers and 293 2-shift workers) whose work schedules remained constant during the follow-up period (mean follow-up period 9.9 years). IGT was defined as Hemoglobin A1c ≥5.9%. The Cox proportional hazards model was used to estimate the risk of developing IGT, after making adjustments for age, smoking, alcohol consumption, leisure-time physical activity, body mass index (BMI) and Hemoglobin A1c (HbA1c) at baseline. Analysis was additionally performed for a sub-cohort of 1625 workers with BMI of 20.0–25.0 kg/m^2 that did not change by >2.0 kg/m^2 during the follow up period. RESULTS: The risk of developing IGT was significantly elevated among both 3-shift workers [hazard ratio (HR) 1.78, 95% confidence interval (95% CI) 1.49– 2.14] and 2-shift workers (HR 2.62, 95% CI 2.17–3.17). Significant elevations of the risk were still observed at the additional analysis on the sub-cohort (3-shift work: HR 3.55, 95% CI 2.02–6.25; 2-shift work: HR 4.86, 95% CI 2.62–9.01). CONCLUSIONS: Both 2- and 3-shift workers were associated with a high risk factor of developing IGT compared to day workers. Moreover, 2-shift workers had a higher risk than 3-shift workers. The risk was observed even among workers whose body mass remained within the normal range. |
| first_indexed | 2024-12-20T00:07:17Z |
| format | Article |
| id | doaj.art-635f934ffd1646848eecfdef0d5ae9f0 |
| institution | Directory Open Access Journal |
| issn | 0355-3140 1795-990X |
| language | English |
| last_indexed | 2024-12-20T00:07:17Z |
| publishDate | 2012-07-01 |
| publisher | Nordic Association of Occupational Safety and Health (NOROSH) |
| record_format | Article |
| series | Scandinavian Journal of Work, Environment & Health |
| spelling | doaj.art-635f934ffd1646848eecfdef0d5ae9f02022-12-21T20:00:36ZengNordic Association of Occupational Safety and Health (NOROSH)Scandinavian Journal of Work, Environment & Health0355-31401795-990X2012-07-0138433734210.5271/sjweh.32973297Retrospective cohort study of the risk of impaired glucose tolerance among shift workersIchiro OyamaTomohide Kubo0Yoshihisa FujinoKoji KadowakiMasamizu KunimotoKiyoyumi ShiraneHidetoshi TabataKen SabanaiTakehiro NakamuraShinya MatsudaDepartment of Public Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan.OBJECTIVES: The aim of this study was to investigate the effect of shift working on the risk of developing impaired glucose tolerance (IGT). METHODS: This study comprised 6413 male employees (5608 daytime workers, 512 3-shift workers and 293 2-shift workers) whose work schedules remained constant during the follow-up period (mean follow-up period 9.9 years). IGT was defined as Hemoglobin A1c ≥5.9%. The Cox proportional hazards model was used to estimate the risk of developing IGT, after making adjustments for age, smoking, alcohol consumption, leisure-time physical activity, body mass index (BMI) and Hemoglobin A1c (HbA1c) at baseline. Analysis was additionally performed for a sub-cohort of 1625 workers with BMI of 20.0–25.0 kg/m^2 that did not change by >2.0 kg/m^2 during the follow up period. RESULTS: The risk of developing IGT was significantly elevated among both 3-shift workers [hazard ratio (HR) 1.78, 95% confidence interval (95% CI) 1.49– 2.14] and 2-shift workers (HR 2.62, 95% CI 2.17–3.17). Significant elevations of the risk were still observed at the additional analysis on the sub-cohort (3-shift work: HR 3.55, 95% CI 2.02–6.25; 2-shift work: HR 4.86, 95% CI 2.62–9.01). CONCLUSIONS: Both 2- and 3-shift workers were associated with a high risk factor of developing IGT compared to day workers. Moreover, 2-shift workers had a higher risk than 3-shift workers. The risk was observed even among workers whose body mass remained within the normal range. https://www.sjweh.fi/show_abstract.php?abstract_id=3297 retrospective cohort studyimpaired glucose toleranceglucoseglucose metabolism disorderhistorical cohort studycohort studyjapanshift workshift workerretrospective studywork schedule tolerance |
| spellingShingle | Ichiro Oyama Tomohide Kubo Yoshihisa Fujino Koji Kadowaki Masamizu Kunimoto Kiyoyumi Shirane Hidetoshi Tabata Ken Sabanai Takehiro Nakamura Shinya Matsuda Retrospective cohort study of the risk of impaired glucose tolerance among shift workers Scandinavian Journal of Work, Environment & Health retrospective cohort study impaired glucose tolerance glucose glucose metabolism disorder historical cohort study cohort study japan shift work shift worker retrospective study work schedule tolerance |
| title | Retrospective cohort study of the risk of impaired glucose tolerance among shift workers |
| title_full | Retrospective cohort study of the risk of impaired glucose tolerance among shift workers |
| title_fullStr | Retrospective cohort study of the risk of impaired glucose tolerance among shift workers |
| title_full_unstemmed | Retrospective cohort study of the risk of impaired glucose tolerance among shift workers |
| title_short | Retrospective cohort study of the risk of impaired glucose tolerance among shift workers |
| title_sort | retrospective cohort study of the risk of impaired glucose tolerance among shift workers |
| topic | retrospective cohort study impaired glucose tolerance glucose glucose metabolism disorder historical cohort study cohort study japan shift work shift worker retrospective study work schedule tolerance |
| url |
https://www.sjweh.fi/show_abstract.php?abstract_id=3297
|
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