Prognostic value of plasma interleukin 6 levels in severe traumatic brain injury
Background: Traumatic brain injury (TBI) results in a significant morbidity and mortality. Several inflammatory mediators are released after TBI. Some studies have shown inconclusive association between interleukin-6 (IL-6) and outcome following TBI. Aims and Objectives: The aim of the present st...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-08-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/52505 |
| _version_ | 1797766655993970688 |
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| author | Afeefah Jamsheed Suhail Sidiq Abdul Qayoom Lone Zaffar Amin |
| author_facet | Afeefah Jamsheed Suhail Sidiq Abdul Qayoom Lone Zaffar Amin |
| author_sort | Afeefah Jamsheed |
| collection | DOAJ |
| description | Background: Traumatic brain injury (TBI) results in a significant morbidity and mortality. Several inflammatory mediators are released after TBI. Some studies have shown inconclusive association between interleukin-6 (IL-6) and outcome following TBI.
Aims and Objectives: The aim of the present study was to investigate the role of plasma IL-6 levels as a possible prognostic marker in patients with severe TBI.
Materials and Methods: A total of 47 male patients with isolated severe TBI were included in a prospective observational study. Plasma IL-6 levels was measured at admission, 24 h and 48 h. Association of IL-6 levels with mortality and functional outcome were studied. The Glasgow outcome scale was used to assess functional outcomes.
Results: Mean age was 44.4 years. Overall mortality of 42.6% was noted. Higher mortality was noted for patients beyond 50 years of age. Mean IL-6 levels at the time of admission was 306.285 pg/mL and 167.830 pg/mL at 24 h while 99.033 pg/mL at 48 h of admission Mean IL 6 levels were higher in patients with lower Glasgow coma scale (GCS), with a significant statistical association of GCS with IL-6 levels at admission and 24 h (P<0.001). 38 (80.85%) patients underwent surgical intervention. No statistical correlation was noted between IL-6 levels and mode of management. Significant IL-6 levels were seen in patients with worse clinical course at admission, 24 h and 48 h (P<0.0001). A level of 78 pg/mL was the appropriate cutoff to differentiate patient mortality as per receiver operating characteristic curve with Sensitivity of 1 and specificity of 0.8.
Conclusion: IL-6 plasma concentrations are likely to be a useful parameter for assessing prognosis in severe TBI. |
| first_indexed | 2024-03-12T20:27:17Z |
| format | Article |
| id | doaj.art-635fea48ed4e4f80a756ca2bc8865226 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-03-12T20:27:17Z |
| publishDate | 2023-08-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-635fea48ed4e4f80a756ca2bc88652262023-08-02T00:22:09ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-08-011487379https://doi.org/10.3126/ajms.v14i8.52505Prognostic value of plasma interleukin 6 levels in severe traumatic brain injuryAfeefah Jamsheed 0https://orcid.org/0000-0002-8426-7786Suhail Sidiq 1https://orcid.org/0000-0003-3544-0148Abdul Qayoom Lone 2https://orcid.org/0009-0003-2378-2527Zaffar Amin 3https://orcid.org/0000-0001-9269-9303Postgraduate Resident, Department of Anesthesiology and Critical Care, Sher-I-Kashmir-Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Associate Professor, Department of Critical Care Medicine, Sher-I-Kashmir-Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Professor, Department of Anesthesiology and Critical Care, Sher-I-Kashmir-Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Professor, Department of Immunology and Molecular Medicine, Sher-I-Kashmir-Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India Background: Traumatic brain injury (TBI) results in a significant morbidity and mortality. Several inflammatory mediators are released after TBI. Some studies have shown inconclusive association between interleukin-6 (IL-6) and outcome following TBI. Aims and Objectives: The aim of the present study was to investigate the role of plasma IL-6 levels as a possible prognostic marker in patients with severe TBI. Materials and Methods: A total of 47 male patients with isolated severe TBI were included in a prospective observational study. Plasma IL-6 levels was measured at admission, 24 h and 48 h. Association of IL-6 levels with mortality and functional outcome were studied. The Glasgow outcome scale was used to assess functional outcomes. Results: Mean age was 44.4 years. Overall mortality of 42.6% was noted. Higher mortality was noted for patients beyond 50 years of age. Mean IL-6 levels at the time of admission was 306.285 pg/mL and 167.830 pg/mL at 24 h while 99.033 pg/mL at 48 h of admission Mean IL 6 levels were higher in patients with lower Glasgow coma scale (GCS), with a significant statistical association of GCS with IL-6 levels at admission and 24 h (P<0.001). 38 (80.85%) patients underwent surgical intervention. No statistical correlation was noted between IL-6 levels and mode of management. Significant IL-6 levels were seen in patients with worse clinical course at admission, 24 h and 48 h (P<0.0001). A level of 78 pg/mL was the appropriate cutoff to differentiate patient mortality as per receiver operating characteristic curve with Sensitivity of 1 and specificity of 0.8. Conclusion: IL-6 plasma concentrations are likely to be a useful parameter for assessing prognosis in severe TBI.https://www.nepjol.info/index.php/AJMS/article/view/52505glasgow outcome scale; interleukin-6; traumatic brain injury |
| spellingShingle | Afeefah Jamsheed Suhail Sidiq Abdul Qayoom Lone Zaffar Amin Prognostic value of plasma interleukin 6 levels in severe traumatic brain injury Asian Journal of Medical Sciences glasgow outcome scale; interleukin-6; traumatic brain injury |
| title | Prognostic value of plasma interleukin 6 levels in severe traumatic brain injury |
| title_full | Prognostic value of plasma interleukin 6 levels in severe traumatic brain injury |
| title_fullStr | Prognostic value of plasma interleukin 6 levels in severe traumatic brain injury |
| title_full_unstemmed | Prognostic value of plasma interleukin 6 levels in severe traumatic brain injury |
| title_short | Prognostic value of plasma interleukin 6 levels in severe traumatic brain injury |
| title_sort | prognostic value of plasma interleukin 6 levels in severe traumatic brain injury |
| topic | glasgow outcome scale; interleukin-6; traumatic brain injury |
| url | https://www.nepjol.info/index.php/AJMS/article/view/52505 |
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