Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase
Prior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the α-proteobacterium Caulobacter crescentus. We showed that a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2016-01-01
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| Series: | Communicative & Integrative Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19420889.2015.1125052 |
| _version_ | 1818451774300749824 |
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| author | François Beaufay Xavier De Bolle Régis Hallez |
| author_facet | François Beaufay Xavier De Bolle Régis Hallez |
| author_sort | François Beaufay |
| collection | DOAJ |
| description | Prior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the α-proteobacterium Caulobacter crescentus. We showed that an NAD-dependent glutamate dehydrogenase (GdhZ) coordinates growth with cell division according to its enzymatic activity. Here we report the conserved role of GdhZ in controlling cell division in another α-proteobacterium, the facultative intracellular pathogen Brucella abortus. We also discuss the importance of amino acids as a main carbon source for α-proteobacteria. |
| first_indexed | 2024-12-14T21:12:32Z |
| format | Article |
| id | doaj.art-635fec54c4244bf288d9f0e13764b63b |
| institution | Directory Open Access Journal |
| issn | 1942-0889 |
| language | English |
| last_indexed | 2024-12-14T21:12:32Z |
| publishDate | 2016-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Communicative & Integrative Biology |
| spelling | doaj.art-635fec54c4244bf288d9f0e13764b63b2022-12-21T22:47:11ZengTaylor & Francis GroupCommunicative & Integrative Biology1942-08892016-01-019110.1080/19420889.2015.11250521125052Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenaseFrançois Beaufay0Xavier De Bolle1Régis Hallez2Bacterial Cell cycle & Development (BCcD), URBM, University of NamurBacterial Cell cycle & Development (BCcD), URBM, University of NamurBacterial Cell cycle & Development (BCcD), URBM, University of NamurPrior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the α-proteobacterium Caulobacter crescentus. We showed that an NAD-dependent glutamate dehydrogenase (GdhZ) coordinates growth with cell division according to its enzymatic activity. Here we report the conserved role of GdhZ in controlling cell division in another α-proteobacterium, the facultative intracellular pathogen Brucella abortus. We also discuss the importance of amino acids as a main carbon source for α-proteobacteria.http://dx.doi.org/10.1080/19420889.2015.1125052α-proteobacteriaBrucellaCaulobactercytokinesiscell divisionFstZglutamate dehydrogenaseGdhZ |
| spellingShingle | François Beaufay Xavier De Bolle Régis Hallez Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase Communicative & Integrative Biology α-proteobacteria Brucella Caulobacter cytokinesis cell division FstZ glutamate dehydrogenase GdhZ |
| title | Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase |
| title_full | Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase |
| title_fullStr | Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase |
| title_full_unstemmed | Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase |
| title_short | Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase |
| title_sort | metabolic control of cell division in α proteobacteria by a nad dependent glutamate dehydrogenase |
| topic | α-proteobacteria Brucella Caulobacter cytokinesis cell division FstZ glutamate dehydrogenase GdhZ |
| url | http://dx.doi.org/10.1080/19420889.2015.1125052 |
| work_keys_str_mv | AT francoisbeaufay metaboliccontrolofcelldivisioninaproteobacteriabyanaddependentglutamatedehydrogenase AT xavierdebolle metaboliccontrolofcelldivisioninaproteobacteriabyanaddependentglutamatedehydrogenase AT regishallez metaboliccontrolofcelldivisioninaproteobacteriabyanaddependentglutamatedehydrogenase |