| Summary: | Conflicts of interest: The author declares no conflict of interest. Abstract: This is a brain aspergilloma case in an immunocompetent patient who suffered from a rare fungal infection transmitted from the mediastinum to the brain and eventually caused pancreatitis. This fungal infection affected the thalamus, hypothalamus, and extended to the midbrain. This case showed a good prognosis for the brain aspergilloma without need for any surgical intervention. The radiological documentation for the brain aspergilloma shows a positive response to a combination of voriconazole and Keppra. Keywords: Brain aspergilloma, Aspergilloma, Aspergillus, MRI, CT
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