Rate of Homologous Desensitization and Internalization of the GLP-1 Receptor

Rate of Homologous Desensitization and Internalization of the GLP-1 Receptor

The glucagon-like peptide-1 receptor (GLP-1R) is an important target in the treatment of type 2 diabetes mellitus. The aim of this study was to compare the rate of agonist stimulated desensitization and internalization of GLP-1R. To this end, an N-terminally myc-tagged GLP-1R was stably expressed in...

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Bibliographic Details
Main Authors: Ghina Shaaban, Mabayoje Oriowo, Suleiman Al-Sabah
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Molecules
Subjects:
GLP-1
receptor
desensitization
internalization
Online Access:http://www.mdpi.com/1420-3049/22/1/22

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