Targeting endothelial cells with golden spice curcumin: A promising therapy for cardiometabolic multimorbidity
Cardiometabolic multimorbidity (CMM) is an increasingly significant global public health concern. It encompasses the coexistence of multiple cardiometabolic diseases, including hypertension, stroke, heart disease, atherosclerosis, and T2DM. A crucial component to the development of CMM is the disrup...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661823003092 |
| _version_ | 1797582937261080576 |
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| author | Fei Tang Dong Liu Li Zhang Li-Yue Xu Jing-Nan Zhang Xiao-Lan Zhao Hui Ao Cheng Peng |
| author_facet | Fei Tang Dong Liu Li Zhang Li-Yue Xu Jing-Nan Zhang Xiao-Lan Zhao Hui Ao Cheng Peng |
| author_sort | Fei Tang |
| collection | DOAJ |
| description | Cardiometabolic multimorbidity (CMM) is an increasingly significant global public health concern. It encompasses the coexistence of multiple cardiometabolic diseases, including hypertension, stroke, heart disease, atherosclerosis, and T2DM. A crucial component to the development of CMM is the disruption of endothelial homeostasis. Therefore, therapies targeting endothelial cells through multi-targeted and multi-pathway approaches hold promise for preventing and treatment of CMM. Curcumin, a widely used dietary supplement derived from the golden spice Carcuma longa, has demonstrated remarkable potential in treatment of CMM through its interaction with endothelial cells. Numerous studies have identified various molecular targets of curcumin (such as NF-κB/PI3K/AKT, MAPK/NF-κB/IL-1β, HO-1, NOs, VEGF, ICAM-1 and ROS). These findings highlight the efficacy of curcumin as a therapeutic agent against CMM through the regulation of endothelial function. It is worth noting that there is a close relationship between the progression of CMM and endothelial damage, characterized by oxidative stress, inflammation, abnormal NO bioavailability and cell adhesion. This paper provides a comprehensive review of curcumin, including its availability, pharmacokinetics, pharmaceutics, and therapeutic application in treatment of CMM, as well as the challenges and future prospects for its clinical translation. In summary, curcumin shows promise as a potential treatment option for CMM, particularly due to its ability to target endothelial cells. It represents a novel and natural lead compound that may offer significant therapeutic benefits in the management of CMM. |
| first_indexed | 2024-03-10T23:29:41Z |
| format | Article |
| id | doaj.art-6364733eda12477f89c76735f48c99e3 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-10T23:29:41Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-6364733eda12477f89c76735f48c99e32023-11-19T04:34:16ZengElsevierPharmacological Research1096-11862023-11-01197106953Targeting endothelial cells with golden spice curcumin: A promising therapy for cardiometabolic multimorbidityFei Tang0Dong Liu1Li Zhang2Li-Yue Xu3Jing-Nan Zhang4Xiao-Lan Zhao5Hui Ao6Cheng Peng7Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaKey Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaKey Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaKey Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaKey Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaKey Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, ChinaKey Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Corresponding author at: Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Corresponding author.Cardiometabolic multimorbidity (CMM) is an increasingly significant global public health concern. It encompasses the coexistence of multiple cardiometabolic diseases, including hypertension, stroke, heart disease, atherosclerosis, and T2DM. A crucial component to the development of CMM is the disruption of endothelial homeostasis. Therefore, therapies targeting endothelial cells through multi-targeted and multi-pathway approaches hold promise for preventing and treatment of CMM. Curcumin, a widely used dietary supplement derived from the golden spice Carcuma longa, has demonstrated remarkable potential in treatment of CMM through its interaction with endothelial cells. Numerous studies have identified various molecular targets of curcumin (such as NF-κB/PI3K/AKT, MAPK/NF-κB/IL-1β, HO-1, NOs, VEGF, ICAM-1 and ROS). These findings highlight the efficacy of curcumin as a therapeutic agent against CMM through the regulation of endothelial function. It is worth noting that there is a close relationship between the progression of CMM and endothelial damage, characterized by oxidative stress, inflammation, abnormal NO bioavailability and cell adhesion. This paper provides a comprehensive review of curcumin, including its availability, pharmacokinetics, pharmaceutics, and therapeutic application in treatment of CMM, as well as the challenges and future prospects for its clinical translation. In summary, curcumin shows promise as a potential treatment option for CMM, particularly due to its ability to target endothelial cells. It represents a novel and natural lead compound that may offer significant therapeutic benefits in the management of CMM.http://www.sciencedirect.com/science/article/pii/S1043661823003092CurcuminCardiometabolic multimorbidityCardiovascular diseaseMetabolic diseasesEndothelial cells |
| spellingShingle | Fei Tang Dong Liu Li Zhang Li-Yue Xu Jing-Nan Zhang Xiao-Lan Zhao Hui Ao Cheng Peng Targeting endothelial cells with golden spice curcumin: A promising therapy for cardiometabolic multimorbidity Pharmacological Research Curcumin Cardiometabolic multimorbidity Cardiovascular disease Metabolic diseases Endothelial cells |
| title | Targeting endothelial cells with golden spice curcumin: A promising therapy for cardiometabolic multimorbidity |
| title_full | Targeting endothelial cells with golden spice curcumin: A promising therapy for cardiometabolic multimorbidity |
| title_fullStr | Targeting endothelial cells with golden spice curcumin: A promising therapy for cardiometabolic multimorbidity |
| title_full_unstemmed | Targeting endothelial cells with golden spice curcumin: A promising therapy for cardiometabolic multimorbidity |
| title_short | Targeting endothelial cells with golden spice curcumin: A promising therapy for cardiometabolic multimorbidity |
| title_sort | targeting endothelial cells with golden spice curcumin a promising therapy for cardiometabolic multimorbidity |
| topic | Curcumin Cardiometabolic multimorbidity Cardiovascular disease Metabolic diseases Endothelial cells |
| url | http://www.sciencedirect.com/science/article/pii/S1043661823003092 |
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