Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T
T1 mapping lacks specificity toward a single particular biological feature, however it has the potential to discriminate spinal cord regional tissue organization and characterize tissue microstructural impairments occurring in neurodegenerative pathologies. In this exploratory work, T1 mapping of th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811919308663 |
| _version_ | 1831632105178660864 |
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| author | Aurélien Massire Henitsoa Rasoanandrianina Maxime Guye Virginie Callot |
| author_facet | Aurélien Massire Henitsoa Rasoanandrianina Maxime Guye Virginie Callot |
| author_sort | Aurélien Massire |
| collection | DOAJ |
| description | T1 mapping lacks specificity toward a single particular biological feature, however it has the potential to discriminate spinal cord regional tissue organization and characterize tissue microstructural impairments occurring in neurodegenerative pathologies. In this exploratory work, T1 mapping of the cervical spinal cord with a 300-μm in-plane resolution was performed on fourteen healthy subjects at 7T, using the MP2RAGE sequence. Individual images from C1 to C7 vertebral levels provided a clear delineation of spinal cord anatomical details and substructures including motor columns within gray matter (GM) horns, anterior median fissure, central canal, ventral, lateral and dorsal white matter (WM) fasciculi, and posterior median septum. Group studies highlighted regional T1 differences between regions of interest so far hardly visible at lower spatial resolution. Two-dimensional averaged T1 maps and manual parcellation of GM and WM substructures were built based on these data. Benefiting from the very high spatial resolution achievable at ultra-high field for T1 mapping, this work contributes to improve the in vivo characterization of the cervical spinal cord. By allowing investigation within a wider range of functional regions, it also opens new perspectives for pathology diagnosis such as motor neuron disease, neuropathic pain or refined investigation of neurodegeneration. |
| first_indexed | 2024-12-19T05:13:22Z |
| format | Article |
| id | doaj.art-6364b3e8725642b68fe5cb6aae1a6f40 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-19T05:13:22Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-6364b3e8725642b68fe5cb6aae1a6f402022-12-21T20:34:45ZengElsevierNeuroImage1095-95722020-01-01205116275Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7TAurélien Massire0Henitsoa Rasoanandrianina1Maxime Guye2Virginie Callot3Aix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France; iLab-Spine - Laboratoire international associé - Imagerie et Biomécanique du rachis, FranceAix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France; iLab-Spine - Laboratoire international associé - Imagerie et Biomécanique du rachis, FranceAix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, FranceAix-Marseille Univ, CNRS, CRMBM, Marseille, France; APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France; iLab-Spine - Laboratoire international associé - Imagerie et Biomécanique du rachis, France; Corresponding author. CRMBM-CEMEREM, UMR 7339, CNRS - Aix-Marseille Université, Faculté de Médecine, 27, bd Jean Moulin, 13385, Marseille Cedex 5, France.T1 mapping lacks specificity toward a single particular biological feature, however it has the potential to discriminate spinal cord regional tissue organization and characterize tissue microstructural impairments occurring in neurodegenerative pathologies. In this exploratory work, T1 mapping of the cervical spinal cord with a 300-μm in-plane resolution was performed on fourteen healthy subjects at 7T, using the MP2RAGE sequence. Individual images from C1 to C7 vertebral levels provided a clear delineation of spinal cord anatomical details and substructures including motor columns within gray matter (GM) horns, anterior median fissure, central canal, ventral, lateral and dorsal white matter (WM) fasciculi, and posterior median septum. Group studies highlighted regional T1 differences between regions of interest so far hardly visible at lower spatial resolution. Two-dimensional averaged T1 maps and manual parcellation of GM and WM substructures were built based on these data. Benefiting from the very high spatial resolution achievable at ultra-high field for T1 mapping, this work contributes to improve the in vivo characterization of the cervical spinal cord. By allowing investigation within a wider range of functional regions, it also opens new perspectives for pathology diagnosis such as motor neuron disease, neuropathic pain or refined investigation of neurodegeneration.http://www.sciencedirect.com/science/article/pii/S1053811919308663Spinal cordUltra-high fieldT1 mappingWM/GM substructuresParcellation |
| spellingShingle | Aurélien Massire Henitsoa Rasoanandrianina Maxime Guye Virginie Callot Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T NeuroImage Spinal cord Ultra-high field T1 mapping WM/GM substructures Parcellation |
| title | Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T |
| title_full | Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T |
| title_fullStr | Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T |
| title_full_unstemmed | Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T |
| title_short | Anterior fissure, central canal, posterior septum and more: New insights into the cervical spinal cord gray and white matter regional organization using T1 mapping at 7T |
| title_sort | anterior fissure central canal posterior septum and more new insights into the cervical spinal cord gray and white matter regional organization using t1 mapping at 7t |
| topic | Spinal cord Ultra-high field T1 mapping WM/GM substructures Parcellation |
| url | http://www.sciencedirect.com/science/article/pii/S1053811919308663 |
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