Cost-effectiveness analysis of infant pneumococcal vaccination with PHiD-CV in Korea
Background: Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) can cause invasive pneumococcal diseases (IPD), pneumonia, and acute otitis media (AOM). Both the 10-valent pneumococcal NTHi protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PC...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2017.1362513 |
| _version_ | 1797677548528730112 |
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| author | Xu-Hao Zhang Oscar Leeuwenkamp Kyu-Bin Oh Young Eun Lee Chul-Min Kim |
| author_facet | Xu-Hao Zhang Oscar Leeuwenkamp Kyu-Bin Oh Young Eun Lee Chul-Min Kim |
| author_sort | Xu-Hao Zhang |
| collection | DOAJ |
| description | Background: Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) can cause invasive pneumococcal diseases (IPD), pneumonia, and acute otitis media (AOM). Both the 10-valent pneumococcal NTHi protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV-13) are included in the National Immunization Program for infants in Korea. This study aimed to evaluate the cost-effectiveness of the 3+1 schedule of PHiD-CV versus that of PCV-13 for National Immunization Program in Korea. Methods: A published Markov model was adapted to evaluate the cost-effectiveness of vaccinating the 2012 birth cohort with PHiD-CV vs. PCV-13 from the Korean government perspective over 10 y. Best available published data were used for epidemiology, vaccine efficacy and disutilities. Data on incidence and direct medical costs were taken from the national insurance claims database. Sensitivity analyses were conducted to explore the robustness of the results. Results: PHiD-CV was projected to prevent an additional 195,262 cases of pneumococcal diseases and NTHi-related diseases vs. PCV-13, with a substantially greater reduction in NTHi-related AOM and a comparable reduction in IPD and community-acquired pneumonia. Parity-priced PHiD-CV generated a health gain of about 844 quality-adjusted life years and a total cost-saving of approximately 4 million United States Dollars (USD) over 10 y. 93% of probabilistic simulations found PHiD-CV 3+1 to be the dominant vaccine option. Conclusion: Compared to PCV-13, PHiD-CV was projected to provide similar prevention against IPD and community-acquired pneumonia but would prevent more cases of AOM. Parity-priced PHiD-CV was anticipated to generate substantial cost-savings and health benefits vs. PCV-13 in Korea. |
| first_indexed | 2024-03-11T22:46:51Z |
| format | Article |
| id | doaj.art-6366888e35cc4811a55afc21b2bcba2f |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:46:51Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-6366888e35cc4811a55afc21b2bcba2f2023-09-22T08:17:51ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-01-01141859410.1080/21645515.2017.13625131362513Cost-effectiveness analysis of infant pneumococcal vaccination with PHiD-CV in KoreaXu-Hao Zhang0Oscar Leeuwenkamp1Kyu-Bin Oh2Young Eun Lee3Chul-Min Kim4GSKEclipseGSKIMS HealthThe Catholic University, Seoul St. Mary HospitalBackground: Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) can cause invasive pneumococcal diseases (IPD), pneumonia, and acute otitis media (AOM). Both the 10-valent pneumococcal NTHi protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV-13) are included in the National Immunization Program for infants in Korea. This study aimed to evaluate the cost-effectiveness of the 3+1 schedule of PHiD-CV versus that of PCV-13 for National Immunization Program in Korea. Methods: A published Markov model was adapted to evaluate the cost-effectiveness of vaccinating the 2012 birth cohort with PHiD-CV vs. PCV-13 from the Korean government perspective over 10 y. Best available published data were used for epidemiology, vaccine efficacy and disutilities. Data on incidence and direct medical costs were taken from the national insurance claims database. Sensitivity analyses were conducted to explore the robustness of the results. Results: PHiD-CV was projected to prevent an additional 195,262 cases of pneumococcal diseases and NTHi-related diseases vs. PCV-13, with a substantially greater reduction in NTHi-related AOM and a comparable reduction in IPD and community-acquired pneumonia. Parity-priced PHiD-CV generated a health gain of about 844 quality-adjusted life years and a total cost-saving of approximately 4 million United States Dollars (USD) over 10 y. 93% of probabilistic simulations found PHiD-CV 3+1 to be the dominant vaccine option. Conclusion: Compared to PCV-13, PHiD-CV was projected to provide similar prevention against IPD and community-acquired pneumonia but would prevent more cases of AOM. Parity-priced PHiD-CV was anticipated to generate substantial cost-savings and health benefits vs. PCV-13 in Korea.http://dx.doi.org/10.1080/21645515.2017.1362513cost-effectivenesskoreaphid-cvpneumococcalvaccine |
| spellingShingle | Xu-Hao Zhang Oscar Leeuwenkamp Kyu-Bin Oh Young Eun Lee Chul-Min Kim Cost-effectiveness analysis of infant pneumococcal vaccination with PHiD-CV in Korea Human Vaccines & Immunotherapeutics cost-effectiveness korea phid-cv pneumococcal vaccine |
| title | Cost-effectiveness analysis of infant pneumococcal vaccination with PHiD-CV in Korea |
| title_full | Cost-effectiveness analysis of infant pneumococcal vaccination with PHiD-CV in Korea |
| title_fullStr | Cost-effectiveness analysis of infant pneumococcal vaccination with PHiD-CV in Korea |
| title_full_unstemmed | Cost-effectiveness analysis of infant pneumococcal vaccination with PHiD-CV in Korea |
| title_short | Cost-effectiveness analysis of infant pneumococcal vaccination with PHiD-CV in Korea |
| title_sort | cost effectiveness analysis of infant pneumococcal vaccination with phid cv in korea |
| topic | cost-effectiveness korea phid-cv pneumococcal vaccine |
| url | http://dx.doi.org/10.1080/21645515.2017.1362513 |
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