Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health
Fatty acid-binding protein-4 (FABP4), commonly known as adipocyte-fatty acid-binding protein (A-FABP), is a pleiotropic adipokine that broadly affects immunity and metabolism. It has been increasingly recognized that FABP4 dysfunction is associated with various metabolic syndromes, including obesity...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/16/12655 |
| _version_ | 1797584485410144256 |
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| author | Yue Shi Chi-Chiu Wang Liqun Wu Yunqing Zhang Aimin Xu Yao Wang |
| author_facet | Yue Shi Chi-Chiu Wang Liqun Wu Yunqing Zhang Aimin Xu Yao Wang |
| author_sort | Yue Shi |
| collection | DOAJ |
| description | Fatty acid-binding protein-4 (FABP4), commonly known as adipocyte-fatty acid-binding protein (A-FABP), is a pleiotropic adipokine that broadly affects immunity and metabolism. It has been increasingly recognized that FABP4 dysfunction is associated with various metabolic syndromes, including obesity, diabetes, cardiovascular diseases, and metabolic inflammation. However, its explicit roles within the context of women’s reproduction and pregnancy remain to be investigated. In this review, we collate recent studies probing the influence of FABP4 on female reproduction, pregnancy, and even fetal health. Elevated circulating FABP4 levels have been found to correlate with impaired reproductive function in women, such as polycystic ovary syndrome and endometriosis. Throughout pregnancy, FABP4 affects maternal–fetal interface homeostasis by affecting both glycolipid metabolism and immune tolerance, leading to adverse pregnancy outcomes, including miscarriage, gestational obesity, gestational diabetes, and preeclampsia. Moreover, maternal FABP4 levels exhibit a substantial linkage with the metabolic health of offspring. Herein, we discuss the emerging significance and potential application of FABP4 in reproduction and pregnancy health and delve into its underlying mechanism at molecular levels. |
| first_indexed | 2024-03-10T23:52:22Z |
| format | Article |
| id | doaj.art-636745611406463d91a107de2aa34767 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:52:22Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-636745611406463d91a107de2aa347672023-11-19T01:26:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161265510.3390/ijms241612655Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring HealthYue Shi0Chi-Chiu Wang1Liqun Wu2Yunqing Zhang3Aimin Xu4Yao Wang5The Second Clinical Medical School, Beijing University of Chinese Medicine, Beijing 100078, ChinaDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong KongDepartment of Pediatrics, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, ChinaThe Second Clinical Medical School, Beijing University of Chinese Medicine, Beijing 100078, ChinaState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong KongDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong KongFatty acid-binding protein-4 (FABP4), commonly known as adipocyte-fatty acid-binding protein (A-FABP), is a pleiotropic adipokine that broadly affects immunity and metabolism. It has been increasingly recognized that FABP4 dysfunction is associated with various metabolic syndromes, including obesity, diabetes, cardiovascular diseases, and metabolic inflammation. However, its explicit roles within the context of women’s reproduction and pregnancy remain to be investigated. In this review, we collate recent studies probing the influence of FABP4 on female reproduction, pregnancy, and even fetal health. Elevated circulating FABP4 levels have been found to correlate with impaired reproductive function in women, such as polycystic ovary syndrome and endometriosis. Throughout pregnancy, FABP4 affects maternal–fetal interface homeostasis by affecting both glycolipid metabolism and immune tolerance, leading to adverse pregnancy outcomes, including miscarriage, gestational obesity, gestational diabetes, and preeclampsia. Moreover, maternal FABP4 levels exhibit a substantial linkage with the metabolic health of offspring. Herein, we discuss the emerging significance and potential application of FABP4 in reproduction and pregnancy health and delve into its underlying mechanism at molecular levels.https://www.mdpi.com/1422-0067/24/16/12655FABP4metabolismimmune regulationwomen reproductionplacentapregnancy complications |
| spellingShingle | Yue Shi Chi-Chiu Wang Liqun Wu Yunqing Zhang Aimin Xu Yao Wang Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health International Journal of Molecular Sciences FABP4 metabolism immune regulation women reproduction placenta pregnancy complications |
| title | Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health |
| title_full | Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health |
| title_fullStr | Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health |
| title_full_unstemmed | Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health |
| title_short | Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health |
| title_sort | pathophysiological insight into fatty acid binding protein 4 multifaced roles in reproduction pregnancy and offspring health |
| topic | FABP4 metabolism immune regulation women reproduction placenta pregnancy complications |
| url | https://www.mdpi.com/1422-0067/24/16/12655 |
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