Research and clinical updates on IRAK4 and its roles in inflammation and malignancy: themes and highlights from the 1st symposium on IRAK4 in cancer

Research and clinical updates on IRAK4 and its roles in inflammation and malignancy: themes and highlights from the 1st symposium on IRAK4 in cancer

The intracellular serine/threonine interleukin 1 receptor-associated kinase 4 (IRAK4) is necessary for most signaling by activated Toll-like receptors (TLRs). Activation of IRAK4 drives activation of nuclear factor kappa B (NF-κB) and so promotes cell survival, inflammation, and other aspects of the...

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Bibliographic Details
Main Authors: Guillermo Garcia-Manero, Uwe Platzbecker, Kian-Huat Lim, Grzegorz Nowakowski, Omar Abdel-Wahab, Hagop Kantarjian, Amit Verma, Daniel T. Starczynowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Hematology
Subjects:
IRAK4
inflammasome
myddosome
TLR
AML
MDS
Online Access:https://www.frontiersin.org/articles/10.3389/frhem.2024.1339870/full

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