The Effect of 3-Week Betaine Supplementation on Blood Biomarkers of Cardiometabolic Health in Young Physically Active Males
Betaine (BET) supplementation decreases homocysteine concentration in plasma, but it may also have an adverse effect on health by increasing blood lipid concentrations, at least in overweight and obese individuals. The aim of this study was to evaluate the effect of BET supplementation on the lipid...
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MDPI AG
2022-08-01
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| Online Access: | https://www.mdpi.com/2218-1989/12/8/731 |
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| author | Emilia Zawieja Krzysztof Durkalec-Michalski Agata Muzsik-Kazimierska Agata Chmurzynska |
| author_facet | Emilia Zawieja Krzysztof Durkalec-Michalski Agata Muzsik-Kazimierska Agata Chmurzynska |
| author_sort | Emilia Zawieja |
| collection | DOAJ |
| description | Betaine (BET) supplementation decreases homocysteine concentration in plasma, but it may also have an adverse effect on health by increasing blood lipid concentrations, at least in overweight and obese individuals. The aim of this study was to evaluate the effect of BET supplementation on the lipid profile and concentrations of homocysteine, inflammatory cytokines, and liver enzymes in physically active, healthy males. This was a randomized, placebo (PL)-controlled, double-blinded, crossover trial. BET (2.5 or 5.0 g/d) was administered for 21 days. Before and after supplementation with BET or PL, anthropometric measurements and blood were collected in a fasted state. Our results show that BET supplementation significantly decreased homocysteine concentration (from 17.1 ± 4.0 μmol/L before BET to 15.6 ± 3.5 μmol/L after BET, <i>p</i> = 0.009, η<sup>2</sup> = 0.164). However, the intervention had no effect on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerol, interleukins 1β and 6, and tumour necrosis factor α concentrations, or alanine and aspartate activities. In addition, there were no interactions between the <i>MTHFR</i> genotype and BET dose. In conclusion, BET supplementation may be beneficial for homocysteine concentration in healthy, physically active males, with no detrimental effect on lipid profile. |
| first_indexed | 2024-03-09T12:57:50Z |
| format | Article |
| id | doaj.art-636a402e51544af59170a663098e6661 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T12:57:50Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-636a402e51544af59170a663098e66612023-11-30T21:58:14ZengMDPI AGMetabolites2218-19892022-08-0112873110.3390/metabo12080731The Effect of 3-Week Betaine Supplementation on Blood Biomarkers of Cardiometabolic Health in Young Physically Active MalesEmilia Zawieja0Krzysztof Durkalec-Michalski1Agata Muzsik-Kazimierska2Agata Chmurzynska3Department of Human Nutrition and Dietetics, Poznan University of Life Sciences, 60-624 Poznan, PolandDepartment of Sports Dietetics, Poznan University of Physical Education, 61-871 Poznan, PolandDepartment of Human Nutrition and Dietetics, Poznan University of Life Sciences, 60-624 Poznan, PolandDepartment of Human Nutrition and Dietetics, Poznan University of Life Sciences, 60-624 Poznan, PolandBetaine (BET) supplementation decreases homocysteine concentration in plasma, but it may also have an adverse effect on health by increasing blood lipid concentrations, at least in overweight and obese individuals. The aim of this study was to evaluate the effect of BET supplementation on the lipid profile and concentrations of homocysteine, inflammatory cytokines, and liver enzymes in physically active, healthy males. This was a randomized, placebo (PL)-controlled, double-blinded, crossover trial. BET (2.5 or 5.0 g/d) was administered for 21 days. Before and after supplementation with BET or PL, anthropometric measurements and blood were collected in a fasted state. Our results show that BET supplementation significantly decreased homocysteine concentration (from 17.1 ± 4.0 μmol/L before BET to 15.6 ± 3.5 μmol/L after BET, <i>p</i> = 0.009, η<sup>2</sup> = 0.164). However, the intervention had no effect on total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triacylglycerol, interleukins 1β and 6, and tumour necrosis factor α concentrations, or alanine and aspartate activities. In addition, there were no interactions between the <i>MTHFR</i> genotype and BET dose. In conclusion, BET supplementation may be beneficial for homocysteine concentration in healthy, physically active males, with no detrimental effect on lipid profile.https://www.mdpi.com/2218-1989/12/8/731betaineblood lipidsMTHFRhomocysteinecardiometabolic healthphysical activity |
| spellingShingle | Emilia Zawieja Krzysztof Durkalec-Michalski Agata Muzsik-Kazimierska Agata Chmurzynska The Effect of 3-Week Betaine Supplementation on Blood Biomarkers of Cardiometabolic Health in Young Physically Active Males Metabolites betaine blood lipids MTHFR homocysteine cardiometabolic health physical activity |
| title | The Effect of 3-Week Betaine Supplementation on Blood Biomarkers of Cardiometabolic Health in Young Physically Active Males |
| title_full | The Effect of 3-Week Betaine Supplementation on Blood Biomarkers of Cardiometabolic Health in Young Physically Active Males |
| title_fullStr | The Effect of 3-Week Betaine Supplementation on Blood Biomarkers of Cardiometabolic Health in Young Physically Active Males |
| title_full_unstemmed | The Effect of 3-Week Betaine Supplementation on Blood Biomarkers of Cardiometabolic Health in Young Physically Active Males |
| title_short | The Effect of 3-Week Betaine Supplementation on Blood Biomarkers of Cardiometabolic Health in Young Physically Active Males |
| title_sort | effect of 3 week betaine supplementation on blood biomarkers of cardiometabolic health in young physically active males |
| topic | betaine blood lipids MTHFR homocysteine cardiometabolic health physical activity |
| url | https://www.mdpi.com/2218-1989/12/8/731 |
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