Presence and Distress of Chemotherapy-Induced Peripheral Neuropathy Symptoms in Upper Extremities of Younger and Older Breast Cancer Survivors
Purpose: The purposes of this study were to determine whether the presence of upper extremity chemotherapy-induced peripheral neuropathy (CIPN) symptoms (burning, pins/needles, numbness, pain, and skin crawls) among breast cancer survivors (BCS) varied according to age (≤45 years or 55–70 years) and...
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| Format: | Article |
| Language: | English |
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Advocate Aurora Health
2020-10-01
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| Series: | Journal of Patient-Centered Research and Reviews |
| Subjects: | |
| Online Access: | https://institutionalrepository.aah.org/cgi/viewcontent.cgi?article=1757&context=jpcrr |
| _version_ | 1811174143233622016 |
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| author | Susan Storey Andrea Cohee Diane Von Ah Eric Vachon Noah R. Zanville Patrick O. Monahan Timothy E. Stump Victoria L. Champion |
| author_facet | Susan Storey Andrea Cohee Diane Von Ah Eric Vachon Noah R. Zanville Patrick O. Monahan Timothy E. Stump Victoria L. Champion |
| author_sort | Susan Storey |
| collection | DOAJ |
| description | Purpose: The purposes of this study were to determine whether the presence of upper extremity chemotherapy-induced peripheral neuropathy (CIPN) symptoms (burning, pins/needles, numbness, pain, and skin crawls) among breast cancer survivors (BCS) varied according to age (≤45 years or 55–70 years) and to examine age group differences in upper extremity CIPN symptom distress. Methods: The study was a secondary analysis of younger (n = 505) and older (n = 622) BCS. Inclusion criteria were age of ≤45 years or 55–70 years; patient at 3–8 years postdiagnosis; patient received the chemotherapy regimen of paclitaxel, doxorubicin, and cyclophosphamide; and patient did not have recurrence. The Symptom Survivor Checklist was used to assess presence and distress of upper extremity CIPN symptoms. Analyses explored whether age group predicted CIPN symptom presence and distress while controlling for sociodemographic and medical variables. Results: Older BCS reported fewer pins/needles, numbness, and pain symptoms (odds ratios: 0.623–0.751). Heart disease (odds ratios: 1.59–1.70) and progesterone-negative breast cancer (odds ratio: 0.663) were significantly associated with one or more CIPN symptoms. Symptom distress ratings did not differ by age groups; both age groups indicated distress from CIPN symptoms, with 25% or more reporting distress as “moderately” or “quite a bit.” Conclusions: Younger BCS reported more upper extremity CIPN symptoms. BCS in both groups continued to report bothersome CIPN symptoms years after treatment. Study findings will assist clinicians in identifying BCS at higher risk for upper extremity CIPN as well as inform development of appropriate tailored interventions to mitigate these symptoms and facilitate restoration to age-related baseline function, thereby improving quality of life for BCS. |
| first_indexed | 2024-04-10T17:58:20Z |
| format | Article |
| id | doaj.art-636a9a55f5d44a12bcafd32a6ca1ad96 |
| institution | Directory Open Access Journal |
| issn | 2330-0698 |
| language | English |
| last_indexed | 2024-04-10T17:58:20Z |
| publishDate | 2020-10-01 |
| publisher | Advocate Aurora Health |
| record_format | Article |
| series | Journal of Patient-Centered Research and Reviews |
| spelling | doaj.art-636a9a55f5d44a12bcafd32a6ca1ad962023-02-02T16:47:12ZengAdvocate Aurora HealthJournal of Patient-Centered Research and Reviews2330-06982020-10-017429530310.17294/2330-0698.1757Presence and Distress of Chemotherapy-Induced Peripheral Neuropathy Symptoms in Upper Extremities of Younger and Older Breast Cancer SurvivorsSusan Storey0Andrea Cohee1Diane Von Ah2Eric Vachon3Noah R. Zanville4Patrick O. Monahan5Timothy E. Stump6Victoria L. Champion 7Indiana University School of Nursing, Indianapolis, INIndiana University School of Nursing, Indianapolis, INIndiana University School of Nursing, Indianapolis, INIndiana University School of Nursing, Indianapolis, INMiami Cancer Institute, Baptist Health South Florida, Miami, FLIndiana University School of Medicine, Indianapolis, IN; Richard M. Fairbanks School of Public Health, Indianapolis, INIndiana University School of Medicine, Indianapolis, INIndiana University School of Nursing, Indianapolis, INPurpose: The purposes of this study were to determine whether the presence of upper extremity chemotherapy-induced peripheral neuropathy (CIPN) symptoms (burning, pins/needles, numbness, pain, and skin crawls) among breast cancer survivors (BCS) varied according to age (≤45 years or 55–70 years) and to examine age group differences in upper extremity CIPN symptom distress. Methods: The study was a secondary analysis of younger (n = 505) and older (n = 622) BCS. Inclusion criteria were age of ≤45 years or 55–70 years; patient at 3–8 years postdiagnosis; patient received the chemotherapy regimen of paclitaxel, doxorubicin, and cyclophosphamide; and patient did not have recurrence. The Symptom Survivor Checklist was used to assess presence and distress of upper extremity CIPN symptoms. Analyses explored whether age group predicted CIPN symptom presence and distress while controlling for sociodemographic and medical variables. Results: Older BCS reported fewer pins/needles, numbness, and pain symptoms (odds ratios: 0.623–0.751). Heart disease (odds ratios: 1.59–1.70) and progesterone-negative breast cancer (odds ratio: 0.663) were significantly associated with one or more CIPN symptoms. Symptom distress ratings did not differ by age groups; both age groups indicated distress from CIPN symptoms, with 25% or more reporting distress as “moderately” or “quite a bit.” Conclusions: Younger BCS reported more upper extremity CIPN symptoms. BCS in both groups continued to report bothersome CIPN symptoms years after treatment. Study findings will assist clinicians in identifying BCS at higher risk for upper extremity CIPN as well as inform development of appropriate tailored interventions to mitigate these symptoms and facilitate restoration to age-related baseline function, thereby improving quality of life for BCS.https://institutionalrepository.aah.org/cgi/viewcontent.cgi?article=1757&context=jpcrrbreast cancersurvivorshipchemotherapy-induced peripheral neuropathyupper extremitysymptom bothersymptom distress |
| spellingShingle | Susan Storey Andrea Cohee Diane Von Ah Eric Vachon Noah R. Zanville Patrick O. Monahan Timothy E. Stump Victoria L. Champion Presence and Distress of Chemotherapy-Induced Peripheral Neuropathy Symptoms in Upper Extremities of Younger and Older Breast Cancer Survivors Journal of Patient-Centered Research and Reviews breast cancer survivorship chemotherapy-induced peripheral neuropathy upper extremity symptom bother symptom distress |
| title | Presence and Distress of Chemotherapy-Induced Peripheral Neuropathy Symptoms in Upper Extremities of Younger and Older Breast Cancer Survivors |
| title_full | Presence and Distress of Chemotherapy-Induced Peripheral Neuropathy Symptoms in Upper Extremities of Younger and Older Breast Cancer Survivors |
| title_fullStr | Presence and Distress of Chemotherapy-Induced Peripheral Neuropathy Symptoms in Upper Extremities of Younger and Older Breast Cancer Survivors |
| title_full_unstemmed | Presence and Distress of Chemotherapy-Induced Peripheral Neuropathy Symptoms in Upper Extremities of Younger and Older Breast Cancer Survivors |
| title_short | Presence and Distress of Chemotherapy-Induced Peripheral Neuropathy Symptoms in Upper Extremities of Younger and Older Breast Cancer Survivors |
| title_sort | presence and distress of chemotherapy induced peripheral neuropathy symptoms in upper extremities of younger and older breast cancer survivors |
| topic | breast cancer survivorship chemotherapy-induced peripheral neuropathy upper extremity symptom bother symptom distress |
| url | https://institutionalrepository.aah.org/cgi/viewcontent.cgi?article=1757&context=jpcrr |
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