The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation
Prolonged mechanical ventilation (PMV) is associated with poor outcomes and a high economic cost. The association between protein intake and PMV has rarely been investigated in previous studies. This study aimed to investigate the impact of protein intake on weaning from mechanical ventilation. Pati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/20/4395 |
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| author | Shih-Wei Huang Horng-Chyuan Lin Yu-Feng Chou Ting-Yu Lin Chun-Yu Lo Hung-Yu Huang Yueh-Fu Fang Meng-Heng Hsieh Shu-Min Lin Yu-Lun Lo Meng-Jer Hsieh Kuo-Chin Kao Chun-Yu Lin Chung-Chi Huang |
| author_facet | Shih-Wei Huang Horng-Chyuan Lin Yu-Feng Chou Ting-Yu Lin Chun-Yu Lo Hung-Yu Huang Yueh-Fu Fang Meng-Heng Hsieh Shu-Min Lin Yu-Lun Lo Meng-Jer Hsieh Kuo-Chin Kao Chun-Yu Lin Chung-Chi Huang |
| author_sort | Shih-Wei Huang |
| collection | DOAJ |
| description | Prolonged mechanical ventilation (PMV) is associated with poor outcomes and a high economic cost. The association between protein intake and PMV has rarely been investigated in previous studies. This study aimed to investigate the impact of protein intake on weaning from mechanical ventilation. Patients with the PMV (mechanical ventilation ≥6 h/day for ≥21 days) at our hospital between December 2020 and April 2022 were included in this study. Demographic data, nutrition records, laboratory data, weaning conditions, and survival data were retrieved from the patient’s electronic medical records. A total of 172 patients were eligible for analysis. The patients were divided into two groups: weaning success (<i>n</i> = 109) and weaning failure (<i>n</i> = 63). Patients with daily protein intake greater than 1.2 g/kg/day had significant shorter median days of ventilator use than those with less daily protein intake (36.5 vs. 114 days, respectively, <i>p</i> < 0.0001). Daily protein intake ≥1.065 g/kg/day (odds ratio: 4.97, <i>p</i> = 0.033), daily protein intake ≥1.2 g/kg/day (odds ratio: 89.07, <i>p</i> = 0.001), improvement of serum albumin (odds ratio: 3.68, <i>p</i> = 0.027), and BMI (odds ratio: 1.235, <i>p</i> = 0.014) were independent predictor for successful weaning. The serum creatinine level in the 4th week remained similar in patients with daily protein intake either >1.065 g/kg/day or >1.2 g/kg/day (<i>p</i> = 0.5219 and <i>p</i> = 0.7796, respectively). Higher protein intake may have benefits in weaning in patients with PMV and had no negative impact on renal function. |
| first_indexed | 2024-03-09T19:38:44Z |
| format | Article |
| id | doaj.art-636d9c0ecc044478b40b9597115009eb |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T19:38:44Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-636d9c0ecc044478b40b9597115009eb2023-11-24T01:46:02ZengMDPI AGNutrients2072-66432022-10-011420439510.3390/nu14204395The Impact of Higher Protein Intake in Patients with Prolonged Mechanical VentilationShih-Wei Huang0Horng-Chyuan Lin1Yu-Feng Chou2Ting-Yu Lin3Chun-Yu Lo4Hung-Yu Huang5Yueh-Fu Fang6Meng-Heng Hsieh7Shu-Min Lin8Yu-Lun Lo9Meng-Jer Hsieh10Kuo-Chin Kao11Chun-Yu Lin12Chung-Chi Huang13Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Nutrition, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanDepartment of Thoracic Medicine, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanProlonged mechanical ventilation (PMV) is associated with poor outcomes and a high economic cost. The association between protein intake and PMV has rarely been investigated in previous studies. This study aimed to investigate the impact of protein intake on weaning from mechanical ventilation. Patients with the PMV (mechanical ventilation ≥6 h/day for ≥21 days) at our hospital between December 2020 and April 2022 were included in this study. Demographic data, nutrition records, laboratory data, weaning conditions, and survival data were retrieved from the patient’s electronic medical records. A total of 172 patients were eligible for analysis. The patients were divided into two groups: weaning success (<i>n</i> = 109) and weaning failure (<i>n</i> = 63). Patients with daily protein intake greater than 1.2 g/kg/day had significant shorter median days of ventilator use than those with less daily protein intake (36.5 vs. 114 days, respectively, <i>p</i> < 0.0001). Daily protein intake ≥1.065 g/kg/day (odds ratio: 4.97, <i>p</i> = 0.033), daily protein intake ≥1.2 g/kg/day (odds ratio: 89.07, <i>p</i> = 0.001), improvement of serum albumin (odds ratio: 3.68, <i>p</i> = 0.027), and BMI (odds ratio: 1.235, <i>p</i> = 0.014) were independent predictor for successful weaning. The serum creatinine level in the 4th week remained similar in patients with daily protein intake either >1.065 g/kg/day or >1.2 g/kg/day (<i>p</i> = 0.5219 and <i>p</i> = 0.7796, respectively). Higher protein intake may have benefits in weaning in patients with PMV and had no negative impact on renal function.https://www.mdpi.com/2072-6643/14/20/4395proteinpatients with PMVprolonged mechanical ventilationcaloriesalbuminwhey protein |
| spellingShingle | Shih-Wei Huang Horng-Chyuan Lin Yu-Feng Chou Ting-Yu Lin Chun-Yu Lo Hung-Yu Huang Yueh-Fu Fang Meng-Heng Hsieh Shu-Min Lin Yu-Lun Lo Meng-Jer Hsieh Kuo-Chin Kao Chun-Yu Lin Chung-Chi Huang The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation Nutrients protein patients with PMV prolonged mechanical ventilation calories albumin whey protein |
| title | The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation |
| title_full | The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation |
| title_fullStr | The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation |
| title_full_unstemmed | The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation |
| title_short | The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation |
| title_sort | impact of higher protein intake in patients with prolonged mechanical ventilation |
| topic | protein patients with PMV prolonged mechanical ventilation calories albumin whey protein |
| url | https://www.mdpi.com/2072-6643/14/20/4395 |
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