Thai ethnomedicinal plants as resistant modifying agents for combating <it>Acinetobacter baumannii</it> infections
<p>Abstracts</p> <p>Background</p> <p><it>Acinetobacter baumannii</it> is well-recognized as an important nosocomial pathogen, however, due to their intrinsic resistance to several antibiotics, treatment options are limited. Synergistic effects between antib...
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| Format: | Article |
| Language: | English |
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BMC
2012-04-01
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| Series: | BMC Complementary and Alternative Medicine |
| Online Access: | http://www.biomedcentral.com/1472-6882/12/56 |
| _version_ | 1818150327284662272 |
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| author | Phatthalung Pinanong Chusri Sasitorn Voravuthikunchai Supayang P |
| author_facet | Phatthalung Pinanong Chusri Sasitorn Voravuthikunchai Supayang P |
| author_sort | Phatthalung Pinanong |
| collection | DOAJ |
| description | <p>Abstracts</p> <p>Background</p> <p><it>Acinetobacter baumannii</it> is well-recognized as an important nosocomial pathogen, however, due to their intrinsic resistance to several antibiotics, treatment options are limited. Synergistic effects between antibiotics and medicinal plants, particularly their active components, have intensively been studied as alternative approaches.</p> <p>Methods</p> <p>Fifty-one ethanol extracts obtained from 44 different selected medicinal plant species were tested for resistance modifying agents (RMAs) of novobiocin against <it>A. baumannii</it> using growth inhibition assay.</p> <p>Results</p> <p>At 250 μg/ml, <it>Holarrhena antidysenterica, Punica granatum, Quisqualis indica, Terminalia bellirica, Terminalia chebula,</it> and <it>Terminalia</it> sp. that possessed low intrinsic antibacterial activity significantly enhanced the activity of novobiocin at 1 μg/ml (1/8xminimum inhibitory concentration) against this pathogen. <it>Holarrhena antidysenterica</it> at 7.8 μg/ml demonstrated remarkable resistant modifying ability against <it>A. baumannii</it> in combination with novobiocin. The phytochemical study revealed that constituents of this medicinal plant contain alkaloids, condensed tannins, and triterpenoids.</p> <p>Conclusion</p> <p>The use of <it>Holarrhena antidysenterica</it> in combination with novobiocin provides an effective alternative treatment for multidrug resistant <it>A. baumannii</it> infections.</p> |
| first_indexed | 2024-12-11T13:21:10Z |
| format | Article |
| id | doaj.art-636ea00d4a8a462e8439d42682132789 |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-12-11T13:21:10Z |
| publishDate | 2012-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-636ea00d4a8a462e8439d426821327892022-12-22T01:05:49ZengBMCBMC Complementary and Alternative Medicine1472-68822012-04-011215610.1186/1472-6882-12-56Thai ethnomedicinal plants as resistant modifying agents for combating <it>Acinetobacter baumannii</it> infectionsPhatthalung PinanongChusri SasitornVoravuthikunchai Supayang P<p>Abstracts</p> <p>Background</p> <p><it>Acinetobacter baumannii</it> is well-recognized as an important nosocomial pathogen, however, due to their intrinsic resistance to several antibiotics, treatment options are limited. Synergistic effects between antibiotics and medicinal plants, particularly their active components, have intensively been studied as alternative approaches.</p> <p>Methods</p> <p>Fifty-one ethanol extracts obtained from 44 different selected medicinal plant species were tested for resistance modifying agents (RMAs) of novobiocin against <it>A. baumannii</it> using growth inhibition assay.</p> <p>Results</p> <p>At 250 μg/ml, <it>Holarrhena antidysenterica, Punica granatum, Quisqualis indica, Terminalia bellirica, Terminalia chebula,</it> and <it>Terminalia</it> sp. that possessed low intrinsic antibacterial activity significantly enhanced the activity of novobiocin at 1 μg/ml (1/8xminimum inhibitory concentration) against this pathogen. <it>Holarrhena antidysenterica</it> at 7.8 μg/ml demonstrated remarkable resistant modifying ability against <it>A. baumannii</it> in combination with novobiocin. The phytochemical study revealed that constituents of this medicinal plant contain alkaloids, condensed tannins, and triterpenoids.</p> <p>Conclusion</p> <p>The use of <it>Holarrhena antidysenterica</it> in combination with novobiocin provides an effective alternative treatment for multidrug resistant <it>A. baumannii</it> infections.</p>http://www.biomedcentral.com/1472-6882/12/56 |
| spellingShingle | Phatthalung Pinanong Chusri Sasitorn Voravuthikunchai Supayang P Thai ethnomedicinal plants as resistant modifying agents for combating <it>Acinetobacter baumannii</it> infections BMC Complementary and Alternative Medicine |
| title | Thai ethnomedicinal plants as resistant modifying agents for combating <it>Acinetobacter baumannii</it> infections |
| title_full | Thai ethnomedicinal plants as resistant modifying agents for combating <it>Acinetobacter baumannii</it> infections |
| title_fullStr | Thai ethnomedicinal plants as resistant modifying agents for combating <it>Acinetobacter baumannii</it> infections |
| title_full_unstemmed | Thai ethnomedicinal plants as resistant modifying agents for combating <it>Acinetobacter baumannii</it> infections |
| title_short | Thai ethnomedicinal plants as resistant modifying agents for combating <it>Acinetobacter baumannii</it> infections |
| title_sort | thai ethnomedicinal plants as resistant modifying agents for combating it acinetobacter baumannii it infections |
| url | http://www.biomedcentral.com/1472-6882/12/56 |
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