Different macaque brain network remodeling after spinal cord injury and NT3 treatment
Summary: Graph theory-based analysis describes the brain as a complex network. Only a few studies have examined modular composition and functional connectivity (FC) between modules in patients with spinal cord injury (SCI). Little is known about the longitudinal changes in hubs and topological prope...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223008611 |
| _version_ | 1797829071335325696 |
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| author | Ting Feng Can Zhao Jia-Sheng Rao Xiao-Jun Guo Shu-Sheng Bao Le-Wei He Wen Zhao Zuxiang Liu Zhao-Yang Yang Xiao-Guang Li |
| author_facet | Ting Feng Can Zhao Jia-Sheng Rao Xiao-Jun Guo Shu-Sheng Bao Le-Wei He Wen Zhao Zuxiang Liu Zhao-Yang Yang Xiao-Guang Li |
| author_sort | Ting Feng |
| collection | DOAJ |
| description | Summary: Graph theory-based analysis describes the brain as a complex network. Only a few studies have examined modular composition and functional connectivity (FC) between modules in patients with spinal cord injury (SCI). Little is known about the longitudinal changes in hubs and topological properties at the modular level after SCI and treatment. We analyzed differences in FC and nodal metrics reflecting modular interaction to investigate brain reorganization after SCI-induced compensation and neurotrophin-3 (NT3)–chitosan-induced regeneration. Mean inter-modular FC and participation coefficient of areas related to motor coordination were significantly higher in the treatment animals than in the SCI-only ones at the late stage. The magnocellular part of the red nucleus may reflect the best difference in brain reorganization after SCI and therapy. Treatment can enhance information flows between regions and promote the integration of motor functions to return to normal. These findings may reveal the information processing of disrupted network modules. |
| first_indexed | 2024-04-09T13:14:35Z |
| format | Article |
| id | doaj.art-636ec29cf4144587a977821f5bba2eee |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-09T13:14:35Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-636ec29cf4144587a977821f5bba2eee2023-05-12T04:16:59ZengElsevieriScience2589-00422023-06-01266106784Different macaque brain network remodeling after spinal cord injury and NT3 treatmentTing Feng0Can Zhao1Jia-Sheng Rao2Xiao-Jun Guo3Shu-Sheng Bao4Le-Wei He5Wen Zhao6Zuxiang Liu7Zhao-Yang Yang8Xiao-Guang Li9School of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR ChinaInstitute of Rehabilitation Engineering, China Rehabilitation Science Institute, Beijing, PR ChinaSchool of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China; Corresponding authorSchool of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR ChinaSchool of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR ChinaSchool of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR ChinaDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, PR ChinaState Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China; Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, PR China; Department of Biology, College of Life Sciences, University of Chinese Academy of Sciences, Beijing, PR China; Corresponding authorDepartment of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, PR China; Corresponding authorSchool of Biological Science and Medical Engineering, Beijing Key Laboratory for Biomaterials and Neural Regeneration, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, PR China; Corresponding authorSummary: Graph theory-based analysis describes the brain as a complex network. Only a few studies have examined modular composition and functional connectivity (FC) between modules in patients with spinal cord injury (SCI). Little is known about the longitudinal changes in hubs and topological properties at the modular level after SCI and treatment. We analyzed differences in FC and nodal metrics reflecting modular interaction to investigate brain reorganization after SCI-induced compensation and neurotrophin-3 (NT3)–chitosan-induced regeneration. Mean inter-modular FC and participation coefficient of areas related to motor coordination were significantly higher in the treatment animals than in the SCI-only ones at the late stage. The magnocellular part of the red nucleus may reflect the best difference in brain reorganization after SCI and therapy. Treatment can enhance information flows between regions and promote the integration of motor functions to return to normal. These findings may reveal the information processing of disrupted network modules.http://www.sciencedirect.com/science/article/pii/S2589004223008611Systems neuroscienceTechniques in neuroscience |
| spellingShingle | Ting Feng Can Zhao Jia-Sheng Rao Xiao-Jun Guo Shu-Sheng Bao Le-Wei He Wen Zhao Zuxiang Liu Zhao-Yang Yang Xiao-Guang Li Different macaque brain network remodeling after spinal cord injury and NT3 treatment iScience Systems neuroscience Techniques in neuroscience |
| title | Different macaque brain network remodeling after spinal cord injury and NT3 treatment |
| title_full | Different macaque brain network remodeling after spinal cord injury and NT3 treatment |
| title_fullStr | Different macaque brain network remodeling after spinal cord injury and NT3 treatment |
| title_full_unstemmed | Different macaque brain network remodeling after spinal cord injury and NT3 treatment |
| title_short | Different macaque brain network remodeling after spinal cord injury and NT3 treatment |
| title_sort | different macaque brain network remodeling after spinal cord injury and nt3 treatment |
| topic | Systems neuroscience Techniques in neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223008611 |
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