ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY
ABSTRACT Objective: To evaluate the profile of blood loss and blood transfusions after the introduction of Tranexamic acid (TXA) in a tertiary university hospital in Brazil. Methods: 173 patients were retrospectively divided into two groups: the ones who received TXA and the control group. Hemog...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Ortopedia e Traumatologia
2020-04-01
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| Series: | Acta Ortopédica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522020000200074&tlng=en |
| _version_ | 1798014410324705280 |
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| author | CHILAN BOU GHOSSON LEITE LUCAS VERISSIMO RANZONI PEDRO NOGUEIRA GIGLIO MARCELO BATISTA BONADIO LUCAS DA PONTE MELO MARCO KAWAMURA DEMANGE RICCARDO GOMES GOBBI |
| author_facet | CHILAN BOU GHOSSON LEITE LUCAS VERISSIMO RANZONI PEDRO NOGUEIRA GIGLIO MARCELO BATISTA BONADIO LUCAS DA PONTE MELO MARCO KAWAMURA DEMANGE RICCARDO GOMES GOBBI |
| author_sort | CHILAN BOU GHOSSON LEITE |
| collection | DOAJ |
| description | ABSTRACT Objective: To evaluate the profile of blood loss and blood transfusions after the introduction of Tranexamic acid (TXA) in a tertiary university hospital in Brazil. Methods: 173 patients were retrospectively divided into two groups: the ones who received TXA and the control group. Hemoglobin levels (Hb), drain output, transfusion rates, and thromboembolic events were measured. Results: Among the patients included in this study, 82 cases received TXA. Blood transfusion occurred in 3 cases of the TXA group (3.7%), and in 27 control group cases (29.7%; p < 0.001). The average Hb decrease was 2.7 g/dl (± 1.39) and the median drain output was 270 mL in the TXA group. In the control group, the values were 3.41 g/dl (± 1.34; p < 0.001) and 460 mL (p < 0.001), respectively. Thromboembolic events occurred in 2 TXA group cases (2.4%) and in 3 control group cases (3.3%; p > 0.999). Conclusion: TXA was effective in reducing blood transfusion rates, Hb decrease, and drain output on the 1st postoperative day without increasing thromboembolic events. Level of evidence III, Retrospective comparative study. |
| first_indexed | 2024-04-11T15:16:59Z |
| format | Article |
| id | doaj.art-636fce3ddcbe4cf4bed787cd93bff7c7 |
| institution | Directory Open Access Journal |
| issn | 1413-7852 |
| language | English |
| last_indexed | 2024-04-11T15:16:59Z |
| publishDate | 2020-04-01 |
| publisher | Sociedade Brasileira de Ortopedia e Traumatologia |
| record_format | Article |
| series | Acta Ortopédica Brasileira |
| spelling | doaj.art-636fce3ddcbe4cf4bed787cd93bff7c72022-12-22T04:16:27ZengSociedade Brasileira de Ortopedia e TraumatologiaActa Ortopédica Brasileira1413-78522020-04-01282747710.1590/1413-785220202802228410ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTYCHILAN BOU GHOSSON LEITEhttps://orcid.org/0000-0002-8386-3121LUCAS VERISSIMO RANZONIhttps://orcid.org/0000-0002-6503-5963PEDRO NOGUEIRA GIGLIOhttps://orcid.org/0000-0002-5855-0975MARCELO BATISTA BONADIOhttps://orcid.org/0000-0002-4468-9693LUCAS DA PONTE MELOhttps://orcid.org/0000-0002-1965-2100MARCO KAWAMURA DEMANGEhttps://orcid.org/0000-0003-1999-9478RICCARDO GOMES GOBBIhttps://orcid.org/0000-0002-1715-4343ABSTRACT Objective: To evaluate the profile of blood loss and blood transfusions after the introduction of Tranexamic acid (TXA) in a tertiary university hospital in Brazil. Methods: 173 patients were retrospectively divided into two groups: the ones who received TXA and the control group. Hemoglobin levels (Hb), drain output, transfusion rates, and thromboembolic events were measured. Results: Among the patients included in this study, 82 cases received TXA. Blood transfusion occurred in 3 cases of the TXA group (3.7%), and in 27 control group cases (29.7%; p < 0.001). The average Hb decrease was 2.7 g/dl (± 1.39) and the median drain output was 270 mL in the TXA group. In the control group, the values were 3.41 g/dl (± 1.34; p < 0.001) and 460 mL (p < 0.001), respectively. Thromboembolic events occurred in 2 TXA group cases (2.4%) and in 3 control group cases (3.3%; p > 0.999). Conclusion: TXA was effective in reducing blood transfusion rates, Hb decrease, and drain output on the 1st postoperative day without increasing thromboembolic events. Level of evidence III, Retrospective comparative study.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522020000200074&tlng=enTranexamic AcidBlood TransfusionKnee Replacement Arthroplasty |
| spellingShingle | CHILAN BOU GHOSSON LEITE LUCAS VERISSIMO RANZONI PEDRO NOGUEIRA GIGLIO MARCELO BATISTA BONADIO LUCAS DA PONTE MELO MARCO KAWAMURA DEMANGE RICCARDO GOMES GOBBI ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY Acta Ortopédica Brasileira Tranexamic Acid Blood Transfusion Knee Replacement Arthroplasty |
| title | ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY |
| title_full | ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY |
| title_fullStr | ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY |
| title_full_unstemmed | ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY |
| title_short | ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY |
| title_sort | assessment of the use of tranexamic acid after total knee arthroplasty |
| topic | Tranexamic Acid Blood Transfusion Knee Replacement Arthroplasty |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-78522020000200074&tlng=en |
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