P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities

P301S‐hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau‐induced synaptic toxicities

Abstract Background Human Tau (hTau) accumulation and synapse loss are two pathological hallmarks of tauopathies. However, whether and how hTau exerts toxic effects on synapses remain elusive. Methods Mutated hTau (P301S) was overexpressed in the N2a cell line, primary hippocampal neurons and hippoc...

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Bibliographic Details
Main Authors: Jia‐Zhao Xie, Yao Zhang, Shi‐Hong Li, Hui Wei, Hui‐Ling Yu, Qiu‐Zhi Zhou, Lin‐Yu Wei, Dan Ke, Qun Wang, Ying Yang, Jian‐Zhi Wang
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Clinical and Translational Medicine
Subjects:
acetylation
KEAP1
NRF2
oxidative stress
P301S
synapse loss
Online Access:https://doi.org/10.1002/ctm2.1003

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