Platelet Lysate Inhibits NF-κB Activation and Induces Proliferation and an Alert State in Quiescent Human Umbilical Vein Endothelial Cells Retaining Their Differentiation Capability

Platelet Lysate Inhibits NF-κB Activation and Induces Proliferation and an Alert State in Quiescent Human Umbilical Vein Endothelial Cells Retaining Their Differentiation Capability

Injured blood vessel repair and blood circulation re-establishment are crucial events for tissue repair. We investigated in primary cultures of human umbilical vein endothelial cells (HUVEC), the effects of platelet lysate (PL), a cocktail of factors released by activated platelets following blood v...

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Bibliographic Details
Main Authors: Alessio Romaldini, Valentina Ulivi, Marta Nardini, Maddalena Mastrogiacomo, Ranieri Cancedda, Fiorella Descalzi
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
endothelial cells
human umbilical vein endothelial cells (HUVEC)
platelet lysate (PL)
platelet factors
angiogenesis
ERK
AKT
HMGB-1
Online Access:https://www.mdpi.com/2073-4409/8/4/331

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