TRPA1 channel mediates methylglyoxal-induced mouse bladder dysfunction

TRPA1 channel mediates methylglyoxal-induced mouse bladder dysfunction

Introduction: The transient receptor potential ankyrin 1 channel (TRPA1) is expressed in urothelial cells and bladder nerve endings. Hyperglycemia in diabetic individuals induces accumulation of the highly reactive dicarbonyl compound methylglyoxal (MGO), which modulates TRPA1 activity. Long-term or...

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Bibliographic Details
Main Authors: Akila L. Oliveira, Matheus L. Medeiros, Erick de Toledo Gomes, Glaucia Coelho Mello, Soraia Katia Pereira Costa, Fabíola Z. Mónica, Edson Antunes
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Physiology
Subjects:
urothelium
lamina propria
cystometry
void spot assay
MG-H1
glyoxalase
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1308077/full

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https://www.frontiersin.org/articles/10.3389/fphys.2023.1308077/full

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