TRPA1 channel mediates methylglyoxal-induced mouse bladder dysfunction
Introduction: The transient receptor potential ankyrin 1 channel (TRPA1) is expressed in urothelial cells and bladder nerve endings. Hyperglycemia in diabetic individuals induces accumulation of the highly reactive dicarbonyl compound methylglyoxal (MGO), which modulates TRPA1 activity. Long-term or...
Main Authors: | Akila L. Oliveira, Matheus L. Medeiros, Erick de Toledo Gomes, Glaucia Coelho Mello, Soraia Katia Pereira Costa, Fabíola Z. Mónica, Edson Antunes |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-12-01
|
Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1308077/full |
Similar Items
-
Selective Pharmacological Inhibition of NOX2 by GSK2795039 Improves Bladder Dysfunction in Cyclophosphamide-Induced Cystitis in Mice
by: Mariana G. de Oliveira, et al.
Published: (2022-12-01) -
The Botulinum Treatment of Neurogenic Detrusor Overactivity: The Double-Face of the Neurotoxin
by: Chiara Traini, et al.
Published: (2019-10-01) -
Quantification of Aging-Related Decreases in Sensory Innervation of the Bladder Trigone in Rats
by: Mathijs M. de Rijk, et al.
Published: (2024-02-01) -
Methylglyoxal in Cardiometabolic Disorders: Routes Leading to Pathology Counterbalanced by Treatment Strategies
by: Izabela Berdowska, et al.
Published: (2023-11-01) -
LDH-A Promotes Metabolic Rewiring in Leucocytes from the Intestine of Rats Treated with TNBS
by: Belen Mendoza-Arroyo, et al.
Published: (2023-07-01)