Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysis
Abstract Purpose Results from studies of internal mammary lymph node sentinel biopsy are inconsistent. Methods A comprehensive literature search was conducted in MEDLINE, EMBASE, Scopus, Cochrane database, and Clinical Trials. Studies reporting the rate of internal mammary lymph node sentinel biopsy...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12957-019-1683-8 |
| _version_ | 1818300967977746432 |
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| author | Jing Gong Yongfu Yu Gaosong Wu Congyao Lin Xin Tu |
| author_facet | Jing Gong Yongfu Yu Gaosong Wu Congyao Lin Xin Tu |
| author_sort | Jing Gong |
| collection | DOAJ |
| description | Abstract Purpose Results from studies of internal mammary lymph node sentinel biopsy are inconsistent. Methods A comprehensive literature search was conducted in MEDLINE, EMBASE, Scopus, Cochrane database, and Clinical Trials. Studies reporting the rate of internal mammary lymph node sentinel biopsy (IMN-SLNB) positivity were identified. We performed pooled proportion meta-analysis using random-effects meta-analyses. The correlation of IMN and axillary lymph node (AXN) metastasis was also investigated. Results After application of inclusion and exclusion criteria, a total of 18 articles (total number of patients = 2427) were included. The pooled estimate for IMN-SLNB positivity rate was 15% (95% confidence interval (CI) 12–17%). Significant between-study heterogeneity was observed. Our results indicate that axillary lymph node metastasis is a strong predictor of IMN involvement (OR 6.01, 95% CI, 3.49, 10.34). Conclusion Internal mammary lymph nodes metastasis might be underestimated. Patients with positive axillary lymph nodes have a higher risk of internal lymph nodes metastasis. As a result, IMN-SLNB might be considered in these patients. Future work needs to be done to assess whether pathological confirmed IMN metastasis can affect patients’ survival. |
| first_indexed | 2024-12-13T05:15:32Z |
| format | Article |
| id | doaj.art-637322f5d1224cacb0e7eebe02cecd5b |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-13T05:15:32Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-637322f5d1224cacb0e7eebe02cecd5b2022-12-21T23:58:26ZengBMCWorld Journal of Surgical Oncology1477-78192019-08-011711810.1186/s12957-019-1683-8Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysisJing Gong0Yongfu Yu1Gaosong Wu2Congyao Lin3Xin Tu4Department of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan UniversityDepartment of Clinical Epidemiology, Aarhus UniversityDepartment of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan UniversityDepartment of Thyroid and Breast Surgery, Zhongnan Hospital of Wuhan UniversitySchool of Mechanical Engineering and Electronic Information, China University of GeosciencesAbstract Purpose Results from studies of internal mammary lymph node sentinel biopsy are inconsistent. Methods A comprehensive literature search was conducted in MEDLINE, EMBASE, Scopus, Cochrane database, and Clinical Trials. Studies reporting the rate of internal mammary lymph node sentinel biopsy (IMN-SLNB) positivity were identified. We performed pooled proportion meta-analysis using random-effects meta-analyses. The correlation of IMN and axillary lymph node (AXN) metastasis was also investigated. Results After application of inclusion and exclusion criteria, a total of 18 articles (total number of patients = 2427) were included. The pooled estimate for IMN-SLNB positivity rate was 15% (95% confidence interval (CI) 12–17%). Significant between-study heterogeneity was observed. Our results indicate that axillary lymph node metastasis is a strong predictor of IMN involvement (OR 6.01, 95% CI, 3.49, 10.34). Conclusion Internal mammary lymph nodes metastasis might be underestimated. Patients with positive axillary lymph nodes have a higher risk of internal lymph nodes metastasis. As a result, IMN-SLNB might be considered in these patients. Future work needs to be done to assess whether pathological confirmed IMN metastasis can affect patients’ survival.http://link.springer.com/article/10.1186/s12957-019-1683-8Internal mammary lymph nodeSentinel lymph node biopsyBreast cancerMeta-analysisSystematic reviewBreast Neoplasms |
| spellingShingle | Jing Gong Yongfu Yu Gaosong Wu Congyao Lin Xin Tu Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysis World Journal of Surgical Oncology Internal mammary lymph node Sentinel lymph node biopsy Breast cancer Meta-analysis Systematic review Breast Neoplasms |
| title | Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysis |
| title_full | Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysis |
| title_fullStr | Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysis |
| title_full_unstemmed | Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysis |
| title_short | Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysis |
| title_sort | should internal mammary lymph node sentinel biopsy be performed in breast cancer a systematic review and meta analysis |
| topic | Internal mammary lymph node Sentinel lymph node biopsy Breast cancer Meta-analysis Systematic review Breast Neoplasms |
| url | http://link.springer.com/article/10.1186/s12957-019-1683-8 |
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