Neuropathology in COVID-19 autopsies is defined by microglial activation and lesions of the white matter with emphasis in cerebellar and brain stem areas

Neuropathology in COVID-19 autopsies is defined by microglial activation and lesions of the white matter with emphasis in cerebellar and brain stem areas

IntroductionThis study aimed to investigate microglial and macrophage activation in 17 patients who died in the context of a COVID-19 infection in 2020 and 2021.MethodsThrough immunohistochemical analysis, the lysosomal marker CD68 was used to detect diffuse parenchymal microglial activity, pronounc...

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Bibliographic Details
Main Authors: Julian A. Stein, Manuel Kaes, Sigrun Smola, Walter J. Schulz-Schaeffer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Neurology
Subjects:
COVID-19
neuropathology
macrophage
CD68
immunohistochemistry
CNS infection
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.1229641/full

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