PPARγ Transcription Deficiency Exacerbates High-Fat Diet-Induced Adipocyte Hypertrophy and Insulin Resistance in Mice

PPARγ Transcription Deficiency Exacerbates High-Fat Diet-Induced Adipocyte Hypertrophy and Insulin Resistance in Mice

BackgroundThe transcriptional factor peroxisome proliferator–activated receptor γ (PPARγ) is an important therapeutic target for the treatment of type 2 diabetes. However, the role of the PPARγ transcriptional activity remains ambiguous in its metabolic regulation.MethodsBased on the crystal structu...

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Bibliographic Details
Main Authors: Fusheng Guo, Shuangshuang Xu, Yanlin Zhu, Xing Zheng, Yi Lu, Jui Tu, Ying He, Lihua Jin, Yong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
PPARγ
DNA binding
transcriptional activity
metabolic disorder
mutant
obesity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01285/full

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