Dominance of objects over context in a mediotemporal lobe model of schizophrenia.
BACKGROUND:A large body of evidence suggests impaired context processing in schizophrenia. Here we propose that this impairment arises from defective integration of mediotemporal 'what' and 'where' routes, carrying object and spatial information to the hippocampus. METHODOLOGY AN...
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-08-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2714963?pdf=render |
| _version_ | 1818932351520997376 |
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| author | Lucia M Talamini Martijn Meeter |
| author_facet | Lucia M Talamini Martijn Meeter |
| author_sort | Lucia M Talamini |
| collection | DOAJ |
| description | BACKGROUND:A large body of evidence suggests impaired context processing in schizophrenia. Here we propose that this impairment arises from defective integration of mediotemporal 'what' and 'where' routes, carrying object and spatial information to the hippocampus. METHODOLOGY AND FINDINGS:We have previously shown, in a mediotemporal lobe (MTL) model, that the abnormal connectivity between MTL regions observed in schizophrenia can explain the episodic memory deficits associated with the disorder. Here we show that the same neuropathology leads to several context processing deficits observed in patients with schizophrenia: 1) failure to choose subordinate stimuli over dominant ones when the former fit the context, 2) decreased contextual constraints in memory retrieval, as reflected in increased false alarm rates and 3) impaired retrieval of contextual information in source monitoring. Model analyses show that these deficits occur because the 'schizophrenic MTL' forms fragmented episodic representations, in which objects are overrepresented at the expense of spatial contextual information. CONCLUSIONS AND SIGNIFICANCE:These findings highlight the importance of MTL neuropathology in schizophrenia, demonstrating that it may underlie a broad spectrum of deficits, including context processing and memory impairments. It is argued that these processing deficits may contribute to central schizophrenia symptoms such as contextually inappropriate behavior, associative abnormalities, conversational drift, concreteness and delusions. |
| first_indexed | 2024-12-20T04:31:06Z |
| format | Article |
| id | doaj.art-63762db26a9b4968a0bfd034f621d717 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T04:31:06Z |
| publishDate | 2009-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-63762db26a9b4968a0bfd034f621d7172022-12-21T19:53:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-08-0148e650510.1371/journal.pone.0006505Dominance of objects over context in a mediotemporal lobe model of schizophrenia.Lucia M TalaminiMartijn MeeterBACKGROUND:A large body of evidence suggests impaired context processing in schizophrenia. Here we propose that this impairment arises from defective integration of mediotemporal 'what' and 'where' routes, carrying object and spatial information to the hippocampus. METHODOLOGY AND FINDINGS:We have previously shown, in a mediotemporal lobe (MTL) model, that the abnormal connectivity between MTL regions observed in schizophrenia can explain the episodic memory deficits associated with the disorder. Here we show that the same neuropathology leads to several context processing deficits observed in patients with schizophrenia: 1) failure to choose subordinate stimuli over dominant ones when the former fit the context, 2) decreased contextual constraints in memory retrieval, as reflected in increased false alarm rates and 3) impaired retrieval of contextual information in source monitoring. Model analyses show that these deficits occur because the 'schizophrenic MTL' forms fragmented episodic representations, in which objects are overrepresented at the expense of spatial contextual information. CONCLUSIONS AND SIGNIFICANCE:These findings highlight the importance of MTL neuropathology in schizophrenia, demonstrating that it may underlie a broad spectrum of deficits, including context processing and memory impairments. It is argued that these processing deficits may contribute to central schizophrenia symptoms such as contextually inappropriate behavior, associative abnormalities, conversational drift, concreteness and delusions.http://europepmc.org/articles/PMC2714963?pdf=render |
| spellingShingle | Lucia M Talamini Martijn Meeter Dominance of objects over context in a mediotemporal lobe model of schizophrenia. PLoS ONE |
| title | Dominance of objects over context in a mediotemporal lobe model of schizophrenia. |
| title_full | Dominance of objects over context in a mediotemporal lobe model of schizophrenia. |
| title_fullStr | Dominance of objects over context in a mediotemporal lobe model of schizophrenia. |
| title_full_unstemmed | Dominance of objects over context in a mediotemporal lobe model of schizophrenia. |
| title_short | Dominance of objects over context in a mediotemporal lobe model of schizophrenia. |
| title_sort | dominance of objects over context in a mediotemporal lobe model of schizophrenia |
| url | http://europepmc.org/articles/PMC2714963?pdf=render |
| work_keys_str_mv | AT luciamtalamini dominanceofobjectsovercontextinamediotemporallobemodelofschizophrenia AT martijnmeeter dominanceofobjectsovercontextinamediotemporallobemodelofschizophrenia |