Gamma-aminobutyric acid improves oxidative stress and function of the thyroid in high-fat diet fed mice
Redox status and thyroid functions of diet-induced obesity (DIO) and DIO-resistant (DIO-R) mice from 20-week high-fat diet-fed (HFD) mice were studied (study I). Whether antiobesity action of gamma-aminobutyric acid (GABA) in HFD mice was related to its antioxidative action or improvement in thyroid...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-05-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614000759 |
| _version_ | 1819294283481481216 |
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| author | Zhenxing Xie Shufang Xia Guo-Wei Le |
| author_facet | Zhenxing Xie Shufang Xia Guo-Wei Le |
| author_sort | Zhenxing Xie |
| collection | DOAJ |
| description | Redox status and thyroid functions of diet-induced obesity (DIO) and DIO-resistant (DIO-R) mice from 20-week high-fat diet-fed (HFD) mice were studied (study I). Whether antiobesity action of gamma-aminobutyric acid (GABA) in HFD mice was related to its antioxidative action or improvement in thyroid function was also examined (study II) by GABA in drinking water (0.2, 0.12 and 0.06%). In DIO mice, thyroid stimulating hormone (TSH) remarkably increased, free thyroid hormones (THs) decreased, thyroid structures deformed and expressions of THs synthesis-specific and thyroid antioxidative markers, THs receptors β and deiodinases in hypothalamus and liver decreased. DIO-R mice showed normalized TSH, increased THs and its functions. Three GABA treatments normalized TSH, while 0.2% and 0.12% GABA treatments restored redox status, raised THs excretions and functions. Consequently, Down-regulated thyroid and THs functions in DIO mice accounted for obesity. GABA could prevent obesity by ameliorating oxidative stress and HFD-disrupted functions of thyroid and THs. |
| first_indexed | 2024-12-24T04:23:52Z |
| format | Article |
| id | doaj.art-6377cfb8870c48a399c53011e2c9e1da |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T04:23:52Z |
| publishDate | 2014-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-6377cfb8870c48a399c53011e2c9e1da2022-12-21T17:15:42ZengElsevierJournal of Functional Foods1756-46462014-05-0187686Gamma-aminobutyric acid improves oxidative stress and function of the thyroid in high-fat diet fed miceZhenxing Xie0Shufang Xia1Guo-Wei Le2State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu Province, P.R. ChinaState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu Province, P.R. ChinaState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu Province, P.R. China; Corresponding author. Tel.: +86 510 8591 7789; fax: +86 510 8591 7789.Redox status and thyroid functions of diet-induced obesity (DIO) and DIO-resistant (DIO-R) mice from 20-week high-fat diet-fed (HFD) mice were studied (study I). Whether antiobesity action of gamma-aminobutyric acid (GABA) in HFD mice was related to its antioxidative action or improvement in thyroid function was also examined (study II) by GABA in drinking water (0.2, 0.12 and 0.06%). In DIO mice, thyroid stimulating hormone (TSH) remarkably increased, free thyroid hormones (THs) decreased, thyroid structures deformed and expressions of THs synthesis-specific and thyroid antioxidative markers, THs receptors β and deiodinases in hypothalamus and liver decreased. DIO-R mice showed normalized TSH, increased THs and its functions. Three GABA treatments normalized TSH, while 0.2% and 0.12% GABA treatments restored redox status, raised THs excretions and functions. Consequently, Down-regulated thyroid and THs functions in DIO mice accounted for obesity. GABA could prevent obesity by ameliorating oxidative stress and HFD-disrupted functions of thyroid and THs.http://www.sciencedirect.com/science/article/pii/S1756464614000759ObesityOxidative stressHypothyroidismThyroid stimulating hormoneThyroid hormone |
| spellingShingle | Zhenxing Xie Shufang Xia Guo-Wei Le Gamma-aminobutyric acid improves oxidative stress and function of the thyroid in high-fat diet fed mice Journal of Functional Foods Obesity Oxidative stress Hypothyroidism Thyroid stimulating hormone Thyroid hormone |
| title | Gamma-aminobutyric acid improves oxidative stress and function of the thyroid in high-fat diet fed mice |
| title_full | Gamma-aminobutyric acid improves oxidative stress and function of the thyroid in high-fat diet fed mice |
| title_fullStr | Gamma-aminobutyric acid improves oxidative stress and function of the thyroid in high-fat diet fed mice |
| title_full_unstemmed | Gamma-aminobutyric acid improves oxidative stress and function of the thyroid in high-fat diet fed mice |
| title_short | Gamma-aminobutyric acid improves oxidative stress and function of the thyroid in high-fat diet fed mice |
| title_sort | gamma aminobutyric acid improves oxidative stress and function of the thyroid in high fat diet fed mice |
| topic | Obesity Oxidative stress Hypothyroidism Thyroid stimulating hormone Thyroid hormone |
| url | http://www.sciencedirect.com/science/article/pii/S1756464614000759 |
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