Antiangiogenic Effects of VH02, a Novel Urea Derivative: In Vitro and in Vivo Studies

Antiangiogenic Effects of VH02, a Novel Urea Derivative: In Vitro and in Vivo Studies

Vascular endothelial growth factor receptor 2 (VEGFR2) is a vital target for therapeutic intervention in cancer. We have recently described a computer-based drug design for a small molecule VEGFR2 inhibitor named VH02 (1-((1-(1H-indazol-6-yl)-1H-1,2,3-triazol-4-yl)methyl)-3-(3-chloromethylphenyl)ure...

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Bibliographic Details
Main Authors: Suwadee Phowichit, Miho Kobayashi, Yuriko Fujinoya, Yasufumi Sato, Kingkarn Sanphanya, Opa Vajragupta, Linda Chularojmontri, Suvara K. Wattanapitayakul
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:Molecules
Subjects:
vascular endothelial growth factor receptor 2 (VEGFR2)
structure-based drug design
urea derivatives
angiogenesis
endothelial cells
Online Access:http://www.mdpi.com/1420-3049/21/9/1258

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