Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells

Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells

Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy, and non-leukemic stromal cells (including mesenchymal stem cells, MSCs) are involved in leukemogenesis and show AML-supporting effects. We investigated how constitutive extracellular mediator release by primary human AML cells alt...

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Bibliographic Details
Main Authors: Elise Aasebø, Annette K. Brenner, Maria Hernandez-Valladares, Even Birkeland, Olav Mjaavatten, Håkon Reikvam, Frode Selheim, Frode S. Berven, Øystein Bruserud
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Diseases
Subjects:
acute myeloid leukemia
mesenchymal stem cells
proteomics
conditioned medium
chemokine
vesicle
Online Access:https://www.mdpi.com/2079-9721/9/4/74

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