Combination of T cell-redirecting bispecific antibody ERY974 and chemotherapy reciprocally enhances efficacy against non-inflamed tumours
T-cell redirecting bispecific antibodies have emerged as therapeutic agents to promote T-cell mediated killing of tumor cells. Here the authors show that a combination of chemotherapy and ERY974, a bispecific antibody that targets glypican-3 and CD3, facilitates T cell infiltration and promotes anti...
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Bibliographic Details
| Main Authors: |
Yuji Sano,
Yumiko Azuma,
Toshiaki Tsunenari,
Yoko Kayukawa,
Junko Shinozuka,
Etsuko Fujii,
Jun Amano,
Yukari Nishito,
Toru Maruyama,
Yasuko Kinoshita,
Yuichiro Sakamoto,
Ayae Yoshida,
Yoko Miyazaki,
Yuta Sato,
Chifumi Teramoto-Seida,
Takahiro Ishiguro,
Takayoshi Tanaka,
Takehisa Kitazawa,
Mika Endo |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-32952-3
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