Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides
Thrombin-derived C-terminal peptides (TCPs) have anti-endotoxic functions in wounds by binding to bacterial lipopolysaccharide (LPS) and Gram-negative bacteria. Here authors use a spectrum of biophysical techniques to determine the conformation of a TCP in complex with LPS and define the interaction...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05242-0 |
| _version_ | 1818420004863868928 |
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| author | Rathi Saravanan Daniel A Holdbrook Jitka Petrlova Shalini Singh Nils A Berglund Yeu Khai Choong Sven Kjellström Peter J Bond Martin Malmsten Artur Schmidtchen |
| author_facet | Rathi Saravanan Daniel A Holdbrook Jitka Petrlova Shalini Singh Nils A Berglund Yeu Khai Choong Sven Kjellström Peter J Bond Martin Malmsten Artur Schmidtchen |
| author_sort | Rathi Saravanan |
| collection | DOAJ |
| description | Thrombin-derived C-terminal peptides (TCPs) have anti-endotoxic functions in wounds by binding to bacterial lipopolysaccharide (LPS) and Gram-negative bacteria. Here authors use a spectrum of biophysical techniques to determine the conformation of a TCP in complex with LPS and define the interaction between TCPs and CD14. |
| first_indexed | 2024-12-14T12:47:35Z |
| format | Article |
| id | doaj.art-637ac0a8256041d7988e22fb5b99d12e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T12:47:35Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-637ac0a8256041d7988e22fb5b99d12e2022-12-21T23:00:44ZengNature PortfolioNature Communications2041-17232018-07-019111410.1038/s41467-018-05242-0Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptidesRathi Saravanan0Daniel A Holdbrook1Jitka Petrlova2Shalini Singh3Nils A Berglund4Yeu Khai Choong5Sven Kjellström6Peter J Bond7Martin Malmsten8Artur Schmidtchen9Lee Kong Chian School of Medicine, Nanyang Technological UniversityBioinformatics Institute (A*STAR)Division of Dermatology and Venereology, Department of Clinical Sciences, Lund UniversityDepartment of Pharmacy, Uppsala UniversityBioinformatics Institute (A*STAR)Lee Kong Chian School of Medicine, Nanyang Technological UniversityCentre of Excellence in Biological and Medical Mass Spectrometry (CEBMMS), Biomedical Centre D13, Lund UniversityBioinformatics Institute (A*STAR)Department of Pharmacy, Uppsala UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityThrombin-derived C-terminal peptides (TCPs) have anti-endotoxic functions in wounds by binding to bacterial lipopolysaccharide (LPS) and Gram-negative bacteria. Here authors use a spectrum of biophysical techniques to determine the conformation of a TCP in complex with LPS and define the interaction between TCPs and CD14.https://doi.org/10.1038/s41467-018-05242-0 |
| spellingShingle | Rathi Saravanan Daniel A Holdbrook Jitka Petrlova Shalini Singh Nils A Berglund Yeu Khai Choong Sven Kjellström Peter J Bond Martin Malmsten Artur Schmidtchen Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides Nature Communications |
| title | Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides |
| title_full | Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides |
| title_fullStr | Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides |
| title_full_unstemmed | Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides |
| title_short | Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides |
| title_sort | structural basis for endotoxin neutralisation and anti inflammatory activity of thrombin derived c terminal peptides |
| url | https://doi.org/10.1038/s41467-018-05242-0 |
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