Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency

The WDR5 subunit of the MLL complex enforces active chromatin and can bind RNA; the relationship between these two activities is unclear. Here we identify a RNA binding pocket on WDR5, and discover a WDR5 mutant (F266A) that selectively abrogates RNA binding without affecting MLL complex assembly or...

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Bibliographic Details
Main Authors: Yul W Yang, Ryan A Flynn, Yong Chen, Kun Qu, Bingbing Wan, Kevin C Wang, Ming Lei, Howard Y Chang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-02-01
Series:eLife
Subjects:
long noncoding RNA
active chromatin
embryonic stem cell
trithorax/MLL
Online Access:https://elifesciences.org/articles/02046

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