Yak (Bos grunniens) milk improves bone mass and microarchitecture in mice with osteoporosis
ABSTRACT: The effect of milk on bone health is controversial. In this study, the effects of yak milk in mice with retinoic acid-induced osteoporosis (OP) were evaluated. Yak milk was provided to OP mice as a nutrition supplement for 6 wk. The results showed that yak milk significantly reduced bone t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Journal of Dairy Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022030222004556 |
| _version_ | 1818023218324176896 |
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| author | Xiaotong Li Jin Zhang Xianglin Kong Talaygul Xerenbek Torkun Mamet |
| author_facet | Xiaotong Li Jin Zhang Xianglin Kong Talaygul Xerenbek Torkun Mamet |
| author_sort | Xiaotong Li |
| collection | DOAJ |
| description | ABSTRACT: The effect of milk on bone health is controversial. In this study, the effects of yak milk in mice with retinoic acid-induced osteoporosis (OP) were evaluated. Yak milk was provided to OP mice as a nutrition supplement for 6 wk. The results showed that yak milk significantly reduced bone turnover markers (tartrate acid phosphatase and alkaline phosphatase). The yak milk treatment was also associated with remarkably increased bone mineral density, bone volume, trabecular thickness, and trabecular number, as well as improved biomechanical properties (maximum load and stress) of the tibia. Furthermore, yak milk mitigated the deterioration of the network and thickness of trabecular bone in treated OP mice compared with the OP model group. The results indicated that yak milk could improve bone mass and microarchitecture through the inhibition of bone resorption in OP mice. |
| first_indexed | 2024-12-10T03:40:49Z |
| format | Article |
| id | doaj.art-637bb75b534947d788e746f4e347feb3 |
| institution | Directory Open Access Journal |
| issn | 0022-0302 |
| language | English |
| last_indexed | 2024-12-10T03:40:49Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Dairy Science |
| spelling | doaj.art-637bb75b534947d788e746f4e347feb32022-12-22T02:03:35ZengElsevierJournal of Dairy Science0022-03022022-10-011051078787890Yak (Bos grunniens) milk improves bone mass and microarchitecture in mice with osteoporosisXiaotong Li0Jin Zhang1Xianglin Kong2Talaygul Xerenbek3Torkun Mamet4Department of Food Science and Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaDepartment of Food Science and Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaDepartment of Food Science and Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, ChinaThe First People's Hospital of Kashgar Prefecture, Kashgar 844000, ChinaDepartment of Food Science and Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China; Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, Xinjiang University, Urumqi 830046, China; Corresponding authorABSTRACT: The effect of milk on bone health is controversial. In this study, the effects of yak milk in mice with retinoic acid-induced osteoporosis (OP) were evaluated. Yak milk was provided to OP mice as a nutrition supplement for 6 wk. The results showed that yak milk significantly reduced bone turnover markers (tartrate acid phosphatase and alkaline phosphatase). The yak milk treatment was also associated with remarkably increased bone mineral density, bone volume, trabecular thickness, and trabecular number, as well as improved biomechanical properties (maximum load and stress) of the tibia. Furthermore, yak milk mitigated the deterioration of the network and thickness of trabecular bone in treated OP mice compared with the OP model group. The results indicated that yak milk could improve bone mass and microarchitecture through the inhibition of bone resorption in OP mice.http://www.sciencedirect.com/science/article/pii/S0022030222004556yak milkosteoporosisbonemicroarchitecture |
| spellingShingle | Xiaotong Li Jin Zhang Xianglin Kong Talaygul Xerenbek Torkun Mamet Yak (Bos grunniens) milk improves bone mass and microarchitecture in mice with osteoporosis Journal of Dairy Science yak milk osteoporosis bone microarchitecture |
| title | Yak (Bos grunniens) milk improves bone mass and microarchitecture in mice with osteoporosis |
| title_full | Yak (Bos grunniens) milk improves bone mass and microarchitecture in mice with osteoporosis |
| title_fullStr | Yak (Bos grunniens) milk improves bone mass and microarchitecture in mice with osteoporosis |
| title_full_unstemmed | Yak (Bos grunniens) milk improves bone mass and microarchitecture in mice with osteoporosis |
| title_short | Yak (Bos grunniens) milk improves bone mass and microarchitecture in mice with osteoporosis |
| title_sort | yak bos grunniens milk improves bone mass and microarchitecture in mice with osteoporosis |
| topic | yak milk osteoporosis bone microarchitecture |
| url | http://www.sciencedirect.com/science/article/pii/S0022030222004556 |
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