Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth
The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underl...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2016-05-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | http://www.endocrineconnections.com/content/5/3/107.full |
| _version_ | 1818578411051810816 |
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| author | Andrew R Dismukes Vanessa J Meyer Elizabeth A Shirtcliff Katherine P Theall Kyle C Esteves Stacy S Drury |
| author_facet | Andrew R Dismukes Vanessa J Meyer Elizabeth A Shirtcliff Katherine P Theall Kyle C Esteves Stacy S Drury |
| author_sort | Andrew R Dismukes |
| collection | DOAJ |
| description | The current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological process that may overlap with TL. One hundred and two participants completed the Trier Social Stressor Test for children (TSST-C). TL was obtained from all youth from buccal swabs on the same day as the TSST-C. Saliva samples from 83 participants were obtained over the course of two additional days to measure waking and diurnal levels of DHEA. DHEA diurnal slope was a robust predictor of TL (B=0.516, P<0.05), while other DHEA values were not significantly associated with TL. This study is one of the first studies to examine basal, diurnal and reactivity measurements of DHEA in youth. Furthermore, this is the first study, to our knowledge, to demonstrate a positive association between DHEA, a putative anti-aging hormone, and TL, an indicator of cellular aging. |
| first_indexed | 2024-12-16T06:45:22Z |
| format | Article |
| id | doaj.art-637ea839639c45f786dece06e8d68bc2 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-16T06:45:22Z |
| publishDate | 2016-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-637ea839639c45f786dece06e8d68bc22022-12-21T22:40:34ZengBioscientificaEndocrine Connections2049-36142049-36142016-05-01531810.1530/EC-16-0007Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youthAndrew R Dismukes0Vanessa J Meyer1Elizabeth A Shirtcliff2Katherine P Theall3Kyle C Esteves4Stacy S Drury5Department of Human Development and Family Studies, Iowa State University, Ames, Iowa, USA, Tulane University School of Medicine, Department of Psychiatry, Division of Child and Adolescent Psychiatry, Tulane University, New Orleans, Louisiana, USADepartment of Human Development and Family Studies, Iowa State University, Ames, Iowa, USA, Tulane University School of Medicine, Department of Psychiatry, Division of Child and Adolescent Psychiatry, Tulane University, New Orleans, Louisiana, USADepartment of Human Development and Family Studies, Iowa State University, Ames, Iowa, USATulane University School of Medicine, Department of Psychiatry, Division of Child and Adolescent Psychiatry, Tulane University, New Orleans, Louisiana, USATulane University School of Medicine, Department of Psychiatry, Division of Child and Adolescent Psychiatry, Tulane University, New Orleans, Louisiana, USATulane University School of Medicine, Department of Psychiatry, Division of Child and Adolescent Psychiatry, Tulane University, New Orleans, Louisiana, USAThe current investigation examined the association between the aging-related biomarkers dehydroepiandrosterone (DHEA) and telomere length (TL) in community-recruited African-American youth. The examination of DHEA included stress reactive, basal and diurnal sampling, in order to elucidate the underlying physiological process that may overlap with TL. One hundred and two participants completed the Trier Social Stressor Test for children (TSST-C). TL was obtained from all youth from buccal swabs on the same day as the TSST-C. Saliva samples from 83 participants were obtained over the course of two additional days to measure waking and diurnal levels of DHEA. DHEA diurnal slope was a robust predictor of TL (B=0.516, P<0.05), while other DHEA values were not significantly associated with TL. This study is one of the first studies to examine basal, diurnal and reactivity measurements of DHEA in youth. Furthermore, this is the first study, to our knowledge, to demonstrate a positive association between DHEA, a putative anti-aging hormone, and TL, an indicator of cellular aging.http://www.endocrineconnections.com/content/5/3/107.fullDHEAtelomeretelomeraseTSSTagingtelomere length |
| spellingShingle | Andrew R Dismukes Vanessa J Meyer Elizabeth A Shirtcliff Katherine P Theall Kyle C Esteves Stacy S Drury Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth Endocrine Connections DHEA telomere telomerase TSST aging telomere length |
| title | Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth |
| title_full | Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth |
| title_fullStr | Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth |
| title_full_unstemmed | Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth |
| title_short | Diurnal and stress-reactive dehydroepiandrosterone levels and telomere length in youth |
| title_sort | diurnal and stress reactive dehydroepiandrosterone levels and telomere length in youth |
| topic | DHEA telomere telomerase TSST aging telomere length |
| url | http://www.endocrineconnections.com/content/5/3/107.full |
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