<i>Ganoderma lucidum</i>: Novel Insight into Hepatoprotective Potential with Mechanisms of Action
<i>Ganoderma lucidum</i> (<i>G. lucidum</i>) has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries. It is currently used as a nutraceutical and functional food owing to its major bioactive compou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/8/1874 |
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| author | Md Faruque Ahmad Fakhruddin Ali Ahmad Md. Zeyaullah Abdulrahman A. Alsayegh Syed Esam Mahmood Abdullah M. AlShahrani Mohammad Suhail Khan Eman Shama Alshaimaa Hamouda Ehab Y. Elbendary Kandil Abdel Hai Ali Attia |
| author_facet | Md Faruque Ahmad Fakhruddin Ali Ahmad Md. Zeyaullah Abdulrahman A. Alsayegh Syed Esam Mahmood Abdullah M. AlShahrani Mohammad Suhail Khan Eman Shama Alshaimaa Hamouda Ehab Y. Elbendary Kandil Abdel Hai Ali Attia |
| author_sort | Md Faruque Ahmad |
| collection | DOAJ |
| description | <i>Ganoderma lucidum</i> (<i>G. lucidum</i>) has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries. It is currently used as a nutraceutical and functional food owing to its major bioactive compounds, polysaccharides and triterpenoids. <i>G. lucidum</i> exhibits a broad range of hepatoprotective impacts in various liver disorders, such as hepatic cancer, nonalcoholic fatty liver disease (NAFLD), alcohol-induced liver disease, hepatitis B, hepatic fibrosis, and liver injury induced by carbon tetrachloride (CCl4) and α-amanitin. <i>G. lucidum</i> protects the liver through a broad range of mechanisms that include the modulation of liver Phase I and II enzymes, the suppression of β-glucuronidase, antifibrotic and antiviral actions, the regulation of the production of nitric oxide (NO), the maintenance of hepatocellular calcium homeostasis, immunomodulatory activity, and scavenging free radicals. <i>G. lucidum</i> could signify an encouraging approach for the management of various chronic hepatopathies, and its potential mechanisms make it a distinctive agent when used alone or with other drugs and applied as a functional food, nutraceutical supplement, or adjuvant to modern medicine. This review summarizes the hepatoprotective properties of <i>G. lucidum</i> with its various mechanisms of action on different liver ailments. Biologically active substances derived from <i>G. lucidum</i> are still being studied for their potential benefits in treating different liver ailments. |
| first_indexed | 2024-03-11T04:40:23Z |
| format | Article |
| id | doaj.art-637f80914423456090ca0e2f241cf188 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T04:40:23Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-637f80914423456090ca0e2f241cf1882023-11-17T20:45:41ZengMDPI AGNutrients2072-66432023-04-01158187410.3390/nu15081874<i>Ganoderma lucidum</i>: Novel Insight into Hepatoprotective Potential with Mechanisms of ActionMd Faruque Ahmad0Fakhruddin Ali Ahmad1Md. Zeyaullah2Abdulrahman A. Alsayegh3Syed Esam Mahmood4Abdullah M. AlShahrani5Mohammad Suhail Khan6Eman Shama7Alshaimaa Hamouda8Ehab Y. Elbendary9Kandil Abdel Hai Ali Attia10Department of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi ArabiaDepartment Forensic Science, School of Engineering and Science, G.D Goenka University, Gurugram 122103, Haryana, IndiaDepartment of Basic Medical Science, College of Applied Medical Sciences, Khamis Mushayt Campus, King Khalid University (KKU), Abha 62561, Saudi ArabiaDepartment of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Family and Community Medicine, College of Medicine, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Basic Medical Science, College of Applied Medical Sciences, Khamis Mushayt Campus, King Khalid University (KKU), Abha 62561, Saudi ArabiaDepartment of Public Health, College of Applied Medical Sciences, Khamis Mushayt Campus, King Khalid University (KKU), Abha 62561, Saudi ArabiaDepartment of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi ArabiaDepartment of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia<i>Ganoderma lucidum</i> (<i>G. lucidum</i>) has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries. It is currently used as a nutraceutical and functional food owing to its major bioactive compounds, polysaccharides and triterpenoids. <i>G. lucidum</i> exhibits a broad range of hepatoprotective impacts in various liver disorders, such as hepatic cancer, nonalcoholic fatty liver disease (NAFLD), alcohol-induced liver disease, hepatitis B, hepatic fibrosis, and liver injury induced by carbon tetrachloride (CCl4) and α-amanitin. <i>G. lucidum</i> protects the liver through a broad range of mechanisms that include the modulation of liver Phase I and II enzymes, the suppression of β-glucuronidase, antifibrotic and antiviral actions, the regulation of the production of nitric oxide (NO), the maintenance of hepatocellular calcium homeostasis, immunomodulatory activity, and scavenging free radicals. <i>G. lucidum</i> could signify an encouraging approach for the management of various chronic hepatopathies, and its potential mechanisms make it a distinctive agent when used alone or with other drugs and applied as a functional food, nutraceutical supplement, or adjuvant to modern medicine. This review summarizes the hepatoprotective properties of <i>G. lucidum</i> with its various mechanisms of action on different liver ailments. Biologically active substances derived from <i>G. lucidum</i> are still being studied for their potential benefits in treating different liver ailments.https://www.mdpi.com/2072-6643/15/8/1874hepatoprotectivenutritional constituentsmechanismscancerNAFLDalcohol |
| spellingShingle | Md Faruque Ahmad Fakhruddin Ali Ahmad Md. Zeyaullah Abdulrahman A. Alsayegh Syed Esam Mahmood Abdullah M. AlShahrani Mohammad Suhail Khan Eman Shama Alshaimaa Hamouda Ehab Y. Elbendary Kandil Abdel Hai Ali Attia <i>Ganoderma lucidum</i>: Novel Insight into Hepatoprotective Potential with Mechanisms of Action Nutrients hepatoprotective nutritional constituents mechanisms cancer NAFLD alcohol |
| title | <i>Ganoderma lucidum</i>: Novel Insight into Hepatoprotective Potential with Mechanisms of Action |
| title_full | <i>Ganoderma lucidum</i>: Novel Insight into Hepatoprotective Potential with Mechanisms of Action |
| title_fullStr | <i>Ganoderma lucidum</i>: Novel Insight into Hepatoprotective Potential with Mechanisms of Action |
| title_full_unstemmed | <i>Ganoderma lucidum</i>: Novel Insight into Hepatoprotective Potential with Mechanisms of Action |
| title_short | <i>Ganoderma lucidum</i>: Novel Insight into Hepatoprotective Potential with Mechanisms of Action |
| title_sort | i ganoderma lucidum i novel insight into hepatoprotective potential with mechanisms of action |
| topic | hepatoprotective nutritional constituents mechanisms cancer NAFLD alcohol |
| url | https://www.mdpi.com/2072-6643/15/8/1874 |
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