Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer
This paper investigates the expression of the CREB1 gene in ovarian cancer (OV) by deeply excavating the gene information in the multiple databases and the mechanism thereof. In short, we found that the expression of the CREB1 gene in ovarian cancer tissue was significantly higher than that of norma...
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| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/4/316 |
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| author | Chia-Jung Li Li-Te Lin Pei-Yi Chu An-Jen Chiang Hsiao-Wen Tsai Yi-Han Chiu Mei-Shu Huang Zhi-Hong Wen Kuan-Hao Tsui |
| author_facet | Chia-Jung Li Li-Te Lin Pei-Yi Chu An-Jen Chiang Hsiao-Wen Tsai Yi-Han Chiu Mei-Shu Huang Zhi-Hong Wen Kuan-Hao Tsui |
| author_sort | Chia-Jung Li |
| collection | DOAJ |
| description | This paper investigates the expression of the CREB1 gene in ovarian cancer (OV) by deeply excavating the gene information in the multiple databases and the mechanism thereof. In short, we found that the expression of the CREB1 gene in ovarian cancer tissue was significantly higher than that of normal ovarian tissue. Kaplan–Meier survival analysis showed that the overall survival was significantly shorter in patients with high expression of the CREB1 gene than those in patients with low expression of the CREB1 gene, and the prognosis of patients with low expression of the CREB1 gene was better. The CREB1 gene may play a role in the occurrence and development of ovarian cancer by regulating the process of protein. Based on differentially expressed genes, 20 small-molecule drugs that potentially target CREB1 with abnormal expression in OV were obtained from the CMap database. Among these compounds, we found that naloxone has the greatest therapeutic value for OV. The high expression of the CREB1 gene may be an indicator of poor prognosis in ovarian cancer patients. Targeting CREB1 may be a potential tool for the diagnosis and treatment of OV. |
| first_indexed | 2024-03-10T12:11:30Z |
| format | Article |
| id | doaj.art-6380286d80be49c28361212964f785a7 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T12:11:30Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-6380286d80be49c28361212964f785a72023-11-21T16:09:28ZengMDPI AGJournal of Personalized Medicine2075-44262021-04-0111431610.3390/jpm11040316Identification of Novel Biomarkers and Candidate Drug in Ovarian CancerChia-Jung Li0Li-Te Lin1Pei-Yi Chu2An-Jen Chiang3Hsiao-Wen Tsai4Yi-Han Chiu5Mei-Shu Huang6Zhi-Hong Wen7Kuan-Hao Tsui8Department of Obstetrics and Gynaecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Obstetrics and Gynaecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanSchool of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242, TaiwanDepartment of Obstetrics and Gynaecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Obstetrics and Gynaecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Microbiology, Soochow University, Taipei 111, TaiwanDepartment of Obstetrics and Gynaecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, TaiwanDepartment of Obstetrics and Gynaecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, TaiwanThis paper investigates the expression of the CREB1 gene in ovarian cancer (OV) by deeply excavating the gene information in the multiple databases and the mechanism thereof. In short, we found that the expression of the CREB1 gene in ovarian cancer tissue was significantly higher than that of normal ovarian tissue. Kaplan–Meier survival analysis showed that the overall survival was significantly shorter in patients with high expression of the CREB1 gene than those in patients with low expression of the CREB1 gene, and the prognosis of patients with low expression of the CREB1 gene was better. The CREB1 gene may play a role in the occurrence and development of ovarian cancer by regulating the process of protein. Based on differentially expressed genes, 20 small-molecule drugs that potentially target CREB1 with abnormal expression in OV were obtained from the CMap database. Among these compounds, we found that naloxone has the greatest therapeutic value for OV. The high expression of the CREB1 gene may be an indicator of poor prognosis in ovarian cancer patients. Targeting CREB1 may be a potential tool for the diagnosis and treatment of OV.https://www.mdpi.com/2075-4426/11/4/316ovarian cancerbioinformaticsCREB1drug perturbation |
| spellingShingle | Chia-Jung Li Li-Te Lin Pei-Yi Chu An-Jen Chiang Hsiao-Wen Tsai Yi-Han Chiu Mei-Shu Huang Zhi-Hong Wen Kuan-Hao Tsui Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer Journal of Personalized Medicine ovarian cancer bioinformatics CREB1 drug perturbation |
| title | Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer |
| title_full | Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer |
| title_fullStr | Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer |
| title_full_unstemmed | Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer |
| title_short | Identification of Novel Biomarkers and Candidate Drug in Ovarian Cancer |
| title_sort | identification of novel biomarkers and candidate drug in ovarian cancer |
| topic | ovarian cancer bioinformatics CREB1 drug perturbation |
| url | https://www.mdpi.com/2075-4426/11/4/316 |
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