coreNASH: Multi‐stakeholder Consensus on Core Outcomes for Decision Making About Nonalcoholic Steatohepatitis Treatment
The increasing prevalence and burden of nonalcoholic steatohepatitis (NASH) has spurred the development of new treatments and a need to consider outcomes used for NASH treatment decision making. Development of a NASH core outcome set (COS) can help prioritize outcomes of highest importance by incorp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2021-05-01
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| Series: | Hepatology Communications |
| Online Access: | https://doi.org/10.1002/hep4.1678 |
| _version_ | 1811173870143537152 |
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| author | Elizabeth Clearfield Veronica Miller Joseph Nadglowski Katherine Barradas Jennifer Al Naber Arun J. Sanyal Brent A. Neuschwander‐Tetri Donna A. Messner the coreNASH Panel |
| author_facet | Elizabeth Clearfield Veronica Miller Joseph Nadglowski Katherine Barradas Jennifer Al Naber Arun J. Sanyal Brent A. Neuschwander‐Tetri Donna A. Messner the coreNASH Panel |
| author_sort | Elizabeth Clearfield |
| collection | DOAJ |
| description | The increasing prevalence and burden of nonalcoholic steatohepatitis (NASH) has spurred the development of new treatments and a need to consider outcomes used for NASH treatment decision making. Development of a NASH core outcome set (COS) can help prioritize outcomes of highest importance by incorporating the perspectives from a variety of decision makers. coreNASH was an initiative to develop a COS for NASH using a modified Delphi consensus process with a multi‐stakeholder voting panel. A candidate outcome list was created based on a literature review and key informant interviews. The candidate outcome list was then condensed and prioritized through three rounds of online voting and through discussion at an in‐person meeting. Outcomes were retained or eliminated based on predetermined consensus criteria, which included special weighting of patients’ opinions in the first two voting rounds. The coreNASH Delphi panel included 53 participants (7 patients, 10 clinicians and researchers, 7 health technology assessors, 22 industry representatives, 2 regulators, and 5 payers) who considered outcomes for two NASH‐related COS: one for NASH without cirrhosis (F2‐F3) and one for NASH with cirrhosis (F4). The initial candidate outcome list for both disease stages included 86 outcomes. The panel agreed on including two core outcomes for NASH without cirrhosis and nine core outcomes for NASH with cirrhosis in the COS. Conclusion: A consensus‐based COS has been developed that can be used across the life cycle of NASH treatments. Outcomes included can contribute to decision making for regulatory, market access, and on‐market decision making. Including the coreNASH COS in clinical development programs will facilitate improved comparisons and help decision makers assess the value of new products. |
| first_indexed | 2024-04-10T17:55:01Z |
| format | Article |
| id | doaj.art-63820c4e29ad4c09b5ddea4cab18df80 |
| institution | Directory Open Access Journal |
| issn | 2471-254X |
| language | English |
| last_indexed | 2024-04-10T17:55:01Z |
| publishDate | 2021-05-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Hepatology Communications |
| spelling | doaj.art-63820c4e29ad4c09b5ddea4cab18df802023-02-02T18:55:15ZengWolters Kluwer Health/LWWHepatology Communications2471-254X2021-05-015577478510.1002/hep4.1678coreNASH: Multi‐stakeholder Consensus on Core Outcomes for Decision Making About Nonalcoholic Steatohepatitis TreatmentElizabeth Clearfield0Veronica Miller1Joseph Nadglowski2Katherine Barradas3Jennifer Al Naber4Arun J. Sanyal5Brent A. Neuschwander‐Tetri6Donna A. Messner7the coreNASH PanelCenter for Medical Technology Policy Baltimore MD USAUniversity of California, Berkeley Berkeley CA USAObesity Action Coalition Tampa FL USAUniversity of California, Berkeley Berkeley CA USACenter for Medical Technology Policy Baltimore MD USAVirginia Commonwealth University Richmond VA USASaint Louis University St. Louis MO USACenter for Medical Technology Policy Baltimore MD USAThe increasing prevalence and burden of nonalcoholic steatohepatitis (NASH) has spurred the development of new treatments and a need to consider outcomes used for NASH treatment decision making. Development of a NASH core outcome set (COS) can help prioritize outcomes of highest importance by incorporating the perspectives from a variety of decision makers. coreNASH was an initiative to develop a COS for NASH using a modified Delphi consensus process with a multi‐stakeholder voting panel. A candidate outcome list was created based on a literature review and key informant interviews. The candidate outcome list was then condensed and prioritized through three rounds of online voting and through discussion at an in‐person meeting. Outcomes were retained or eliminated based on predetermined consensus criteria, which included special weighting of patients’ opinions in the first two voting rounds. The coreNASH Delphi panel included 53 participants (7 patients, 10 clinicians and researchers, 7 health technology assessors, 22 industry representatives, 2 regulators, and 5 payers) who considered outcomes for two NASH‐related COS: one for NASH without cirrhosis (F2‐F3) and one for NASH with cirrhosis (F4). The initial candidate outcome list for both disease stages included 86 outcomes. The panel agreed on including two core outcomes for NASH without cirrhosis and nine core outcomes for NASH with cirrhosis in the COS. Conclusion: A consensus‐based COS has been developed that can be used across the life cycle of NASH treatments. Outcomes included can contribute to decision making for regulatory, market access, and on‐market decision making. Including the coreNASH COS in clinical development programs will facilitate improved comparisons and help decision makers assess the value of new products.https://doi.org/10.1002/hep4.1678 |
| spellingShingle | Elizabeth Clearfield Veronica Miller Joseph Nadglowski Katherine Barradas Jennifer Al Naber Arun J. Sanyal Brent A. Neuschwander‐Tetri Donna A. Messner the coreNASH Panel coreNASH: Multi‐stakeholder Consensus on Core Outcomes for Decision Making About Nonalcoholic Steatohepatitis Treatment Hepatology Communications |
| title | coreNASH: Multi‐stakeholder Consensus on Core Outcomes for Decision Making About Nonalcoholic Steatohepatitis Treatment |
| title_full | coreNASH: Multi‐stakeholder Consensus on Core Outcomes for Decision Making About Nonalcoholic Steatohepatitis Treatment |
| title_fullStr | coreNASH: Multi‐stakeholder Consensus on Core Outcomes for Decision Making About Nonalcoholic Steatohepatitis Treatment |
| title_full_unstemmed | coreNASH: Multi‐stakeholder Consensus on Core Outcomes for Decision Making About Nonalcoholic Steatohepatitis Treatment |
| title_short | coreNASH: Multi‐stakeholder Consensus on Core Outcomes for Decision Making About Nonalcoholic Steatohepatitis Treatment |
| title_sort | corenash multi stakeholder consensus on core outcomes for decision making about nonalcoholic steatohepatitis treatment |
| url | https://doi.org/10.1002/hep4.1678 |
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