Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study.
The objective of the present study was to examine the associations between metabolic syndrome (MS) components, such as overweight (OW), hypertension (HT), dyslipidemia (DL), and impaired glucose tolerance (IGT), and intervertebral disc degeneration (DD).The present study included 928 participants (3...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4739731?pdf=render |
| _version_ | 1828342229871099904 |
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| author | Masatoshi Teraguchi Noriko Yoshimura Hiroshi Hashizume Shigeyuki Muraki Hiroshi Yamada Hiroyuki Oka Akihito Minamide Yuyu Ishimoto Keiji Nagata Ryohei Kagotani Sakae Tanaka Hiroshi Kawaguchi Kozo Nakamura Toru Akune Munehito Yoshida |
| author_facet | Masatoshi Teraguchi Noriko Yoshimura Hiroshi Hashizume Shigeyuki Muraki Hiroshi Yamada Hiroyuki Oka Akihito Minamide Yuyu Ishimoto Keiji Nagata Ryohei Kagotani Sakae Tanaka Hiroshi Kawaguchi Kozo Nakamura Toru Akune Munehito Yoshida |
| author_sort | Masatoshi Teraguchi |
| collection | DOAJ |
| description | The objective of the present study was to examine the associations between metabolic syndrome (MS) components, such as overweight (OW), hypertension (HT), dyslipidemia (DL), and impaired glucose tolerance (IGT), and intervertebral disc degeneration (DD).The present study included 928 participants (308 men, 620 women) of the 1,011 participants in the Wakayama Spine Study. DD on magnetic resonance imaging was classified according to the Pfirrmann system. OW, HT, DL, and IGT were assessed using the criteria of the Examination Committee of Criteria for MS in Japan.Multivariable logistic regression analysis revealed that OW was significantly associated with cervical, thoracic, and lumbar DD (cervical: odds ratio [OR], 1.28; 95% confidence interval [CI], 0.92-1.78; thoracic: OR, 1.75; 95% CI, 1.24-2.51; lumbar: OR, 1.87; 95% CI, 1.06-3.48). HT and IGT were significantly associated with thoracic DD (HT: OR, 1.54; 95% CI, 1.09-2.18; IGT: OR, 1.65; 95% CI, 1.12-2.48). Furthermore, subjects with 1 or more MS components had a higher OR for thoracic DD compared with those without MS components (vs. no component; 1 component: OR, 1.58; 95% CI, 1.03-2.42; 2 components: OR, 2.60; 95% CI, 1.62-4.20; ≥3 components: OR, 2.62; 95% CI, 1.42-5.00).MS components were significantly associated with thoracic DD. Furthermore, accumulation of MS components significantly increased the OR for thoracic DD. These findings support the need for further studies of the effects of metabolic abnormality on DD. |
| first_indexed | 2024-04-13T23:26:03Z |
| format | Article |
| id | doaj.art-6383fce50fdf46968407d47a04f0358d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T23:26:03Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-6383fce50fdf46968407d47a04f0358d2022-12-22T02:25:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014756510.1371/journal.pone.0147565Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study.Masatoshi TeraguchiNoriko YoshimuraHiroshi HashizumeShigeyuki MurakiHiroshi YamadaHiroyuki OkaAkihito MinamideYuyu IshimotoKeiji NagataRyohei KagotaniSakae TanakaHiroshi KawaguchiKozo NakamuraToru AkuneMunehito YoshidaThe objective of the present study was to examine the associations between metabolic syndrome (MS) components, such as overweight (OW), hypertension (HT), dyslipidemia (DL), and impaired glucose tolerance (IGT), and intervertebral disc degeneration (DD).The present study included 928 participants (308 men, 620 women) of the 1,011 participants in the Wakayama Spine Study. DD on magnetic resonance imaging was classified according to the Pfirrmann system. OW, HT, DL, and IGT were assessed using the criteria of the Examination Committee of Criteria for MS in Japan.Multivariable logistic regression analysis revealed that OW was significantly associated with cervical, thoracic, and lumbar DD (cervical: odds ratio [OR], 1.28; 95% confidence interval [CI], 0.92-1.78; thoracic: OR, 1.75; 95% CI, 1.24-2.51; lumbar: OR, 1.87; 95% CI, 1.06-3.48). HT and IGT were significantly associated with thoracic DD (HT: OR, 1.54; 95% CI, 1.09-2.18; IGT: OR, 1.65; 95% CI, 1.12-2.48). Furthermore, subjects with 1 or more MS components had a higher OR for thoracic DD compared with those without MS components (vs. no component; 1 component: OR, 1.58; 95% CI, 1.03-2.42; 2 components: OR, 2.60; 95% CI, 1.62-4.20; ≥3 components: OR, 2.62; 95% CI, 1.42-5.00).MS components were significantly associated with thoracic DD. Furthermore, accumulation of MS components significantly increased the OR for thoracic DD. These findings support the need for further studies of the effects of metabolic abnormality on DD.http://europepmc.org/articles/PMC4739731?pdf=render |
| spellingShingle | Masatoshi Teraguchi Noriko Yoshimura Hiroshi Hashizume Shigeyuki Muraki Hiroshi Yamada Hiroyuki Oka Akihito Minamide Yuyu Ishimoto Keiji Nagata Ryohei Kagotani Sakae Tanaka Hiroshi Kawaguchi Kozo Nakamura Toru Akune Munehito Yoshida Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study. PLoS ONE |
| title | Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study. |
| title_full | Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study. |
| title_fullStr | Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study. |
| title_full_unstemmed | Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study. |
| title_short | Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study. |
| title_sort | metabolic syndrome components are associated with intervertebral disc degeneration the wakayama spine study |
| url | http://europepmc.org/articles/PMC4739731?pdf=render |
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