Clinical and pathological characteristics of diquat poisoning-related acute kidney injury
AbstractObjectives Diquat has replaced paraquat in agricultural areas as a herbicide but has led to extensive poisoning. Unlike paraquat, which targets the lungs, diquat primarily targets the kidneys. Autopsies and animal experiments suggest that interstitial kidney damage is the most critical renal...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2283590 |
| _version_ | 1797211808854966272 |
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| author | Ziqin Xia Wenjun Liu Liu Liu |
| author_facet | Ziqin Xia Wenjun Liu Liu Liu |
| author_sort | Ziqin Xia |
| collection | DOAJ |
| description | AbstractObjectives Diquat has replaced paraquat in agricultural areas as a herbicide but has led to extensive poisoning. Unlike paraquat, which targets the lungs, diquat primarily targets the kidneys. Autopsies and animal experiments suggest that interstitial kidney damage is the most critical renal lesion. Diquat is a nonselective chemical widely used for terrestrial and aquatic plants after the ban on paraquat. Although diquat is known to affect the kidneys mainly, no study has reported renal biopsy in patients with diquat poisoning.Methods We investigated the histopathologic feature in a young man with diquat poisoning who developed acute kidney injury by renal biopsy.Results Autopsy and animal experiments suggest that interstitial kidney inflammation is the most critical renal lesion. Surprisingly, our results showed that lipid degeneration and acute tubular injury with limited interstitial inflammation were the dominant histologic findings in this patient.Conclusions Based on a renal biopsy, this was the first study describing the characteristics of the kidney affected by diquat poisoning. Our findings might provide information for managing patients who develop AKI due to diquat poisoning. |
| first_indexed | 2024-03-09T14:34:37Z |
| format | Article |
| id | doaj.art-638583c261ce48e0b1a717039abde765 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-24T10:32:23Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-638583c261ce48e0b1a717039abde7652024-04-12T14:34:28ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145210.1080/0886022X.2023.2283590Clinical and pathological characteristics of diquat poisoning-related acute kidney injuryZiqin Xia0Wenjun Liu1Liu Liu2Department of Nephrology, Qinghai Provincial People’s Hospital, Xining, ChinaDepartment of Nephrology, Xishui County People’s Hospital Affiliated to Hubei University of Science and Technology, Huanggang, ChinaDepartment of Nephrology, Tongji Hospital Affiliated to Tongji Medical College, Huangzhong University of Science and Technology, Wuhan, ChinaAbstractObjectives Diquat has replaced paraquat in agricultural areas as a herbicide but has led to extensive poisoning. Unlike paraquat, which targets the lungs, diquat primarily targets the kidneys. Autopsies and animal experiments suggest that interstitial kidney damage is the most critical renal lesion. Diquat is a nonselective chemical widely used for terrestrial and aquatic plants after the ban on paraquat. Although diquat is known to affect the kidneys mainly, no study has reported renal biopsy in patients with diquat poisoning.Methods We investigated the histopathologic feature in a young man with diquat poisoning who developed acute kidney injury by renal biopsy.Results Autopsy and animal experiments suggest that interstitial kidney inflammation is the most critical renal lesion. Surprisingly, our results showed that lipid degeneration and acute tubular injury with limited interstitial inflammation were the dominant histologic findings in this patient.Conclusions Based on a renal biopsy, this was the first study describing the characteristics of the kidney affected by diquat poisoning. Our findings might provide information for managing patients who develop AKI due to diquat poisoning.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2283590Diquatpoisoningacute tubular necrosisrenal biopsylipid degeneration |
| spellingShingle | Ziqin Xia Wenjun Liu Liu Liu Clinical and pathological characteristics of diquat poisoning-related acute kidney injury Renal Failure Diquat poisoning acute tubular necrosis renal biopsy lipid degeneration |
| title | Clinical and pathological characteristics of diquat poisoning-related acute kidney injury |
| title_full | Clinical and pathological characteristics of diquat poisoning-related acute kidney injury |
| title_fullStr | Clinical and pathological characteristics of diquat poisoning-related acute kidney injury |
| title_full_unstemmed | Clinical and pathological characteristics of diquat poisoning-related acute kidney injury |
| title_short | Clinical and pathological characteristics of diquat poisoning-related acute kidney injury |
| title_sort | clinical and pathological characteristics of diquat poisoning related acute kidney injury |
| topic | Diquat poisoning acute tubular necrosis renal biopsy lipid degeneration |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2283590 |
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