Bruxism Throughout the Lifespan and Variants in <i>MMP2</i>, <i>MMP9</i> and <i>COMT</i>
Bruxism is a masticatory muscle activity characterized by grinding of the teeth and clenching of the jaw that causes tooth wear and breakage, temporomandibular joint disorders, muscle pain, and headache. Bruxism occurs in both adults and children. Clinical characteristics and habits were evaluated i...
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MDPI AG
2020-05-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/10/2/44 |
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| author | Alexandre R. Vieira Rafaela Scariot Jennifer T. Gerber Juliana Arid Erika C. Küchler Aline M. Sebastiani Marcelo Palinkas Kranya V. Díaz-Serrano Carolina P. Torres Simone C. H. Regalo Paulo Nelson-Filho Diego G. Bussaneli Kathleen Deeley Adriana Modesto |
| author_facet | Alexandre R. Vieira Rafaela Scariot Jennifer T. Gerber Juliana Arid Erika C. Küchler Aline M. Sebastiani Marcelo Palinkas Kranya V. Díaz-Serrano Carolina P. Torres Simone C. H. Regalo Paulo Nelson-Filho Diego G. Bussaneli Kathleen Deeley Adriana Modesto |
| author_sort | Alexandre R. Vieira |
| collection | DOAJ |
| description | Bruxism is a masticatory muscle activity characterized by grinding of the teeth and clenching of the jaw that causes tooth wear and breakage, temporomandibular joint disorders, muscle pain, and headache. Bruxism occurs in both adults and children. Clinical characteristics and habits were evaluated in an adult sample. Moreover, we used DNA samples from 349 adults and 151 children to determine the presence of association with specific genes. Genomic DNA was obtained from saliva. The markers <i>rs2241145</i> and <i>rs243832</i> (metalloproteinase 2 (<i>MMP2</i>)), <i>rs13925</i> and <i>rs2236416</i> (metalloproteinase 9 (<i>MMP9</i>)), and <i>rs6269</i> (cathecol-o-methyltransferase (<i>COMT</i>)) were genotyped. Data were submitted to statistical analysis with a significance level of 0.05. In adults, in univariate logistic regression, presence of caries, attrition, and use of alcohol were increased in bruxism individuals (<i>p</i> < 0.05). In addition, in adults, there was an association between bruxism and <i>MMP9</i> (<i>rs13925</i>, <i>p</i> = 0.0001) and bruxism and <i>COMT</i> (<i>rs6269</i>, <i>p</i> = 0.003). In children, a borderline association was observed for <i>MMP9</i> (<i>rs2236416</i>, <i>p</i> = 0.08). When we performed multivariate logistic regression analyses in adults, the same clinical characteristics remained associated with bruxism, and orthodontic treatment was also associated, besides <i>rs13925</i>, in the AG genotype (<i>p</i> = 0.015, OR<sub>a</sub>: 3.40 (1.27–9.07)). For the first time, we provide statistical evidence that these genes are associate with bruxism. |
| first_indexed | 2024-03-10T19:33:41Z |
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| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T19:33:41Z |
| publishDate | 2020-05-01 |
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| spelling | doaj.art-6387f3baa36444c4b8a17825d1eac6342023-11-20T01:55:54ZengMDPI AGJournal of Personalized Medicine2075-44262020-05-011024410.3390/jpm10020044Bruxism Throughout the Lifespan and Variants in <i>MMP2</i>, <i>MMP9</i> and <i>COMT</i>Alexandre R. Vieira0Rafaela Scariot1Jennifer T. Gerber2Juliana Arid3Erika C. Küchler4Aline M. Sebastiani5Marcelo Palinkas6Kranya V. Díaz-Serrano7Carolina P. Torres8Simone C. H. Regalo9Paulo Nelson-Filho10Diego G. Bussaneli11Kathleen Deeley12Adriana Modesto13Department of Oral Biology, University of Pittsburgh School of Dental Medicine, 412 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA 15261, USADepartment of Oral and Maxillofacial Surgery, Positivo University, Curitiba, PR 81280-330, BrazilDepartment of Oral and Maxillofacial Surgery, Positivo University, Curitiba, PR 81280-330, BrazilDepartment of Pediatric Dentistry, USP, Ribeirão Preto, SP 14040-904, BrazilDepartment of Pediatric Dentistry, USP, Ribeirão Preto, SP 14040-904, BrazilDepartment of Oral and Maxillofacial Surgery, Positivo University, Curitiba, PR 81280-330, BrazilDepartment of Pediatric Dentistry, USP, Ribeirão Preto, SP 14040-904, BrazilDepartment of Pediatric Dentistry, USP, Ribeirão Preto, SP 14040-904, BrazilDepartment of Pediatric Dentistry, USP, Ribeirão Preto, SP 14040-904, BrazilDepartment of Morphology, Physiology and Basic Pathology, USP, Ribeirão Preto, SP 14040-904, BrazilDepartment of Pediatric Dentistry, USP, Ribeirão Preto, SP 14040-904, BrazilDepartment of Oral Biology, University of Pittsburgh School of Dental Medicine, 412 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA 15261, USADepartment of Oral Biology, University of Pittsburgh School of Dental Medicine, 412 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA 15261, USADepartment of Oral Biology, University of Pittsburgh School of Dental Medicine, 412 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA 15261, USABruxism is a masticatory muscle activity characterized by grinding of the teeth and clenching of the jaw that causes tooth wear and breakage, temporomandibular joint disorders, muscle pain, and headache. Bruxism occurs in both adults and children. Clinical characteristics and habits were evaluated in an adult sample. Moreover, we used DNA samples from 349 adults and 151 children to determine the presence of association with specific genes. Genomic DNA was obtained from saliva. The markers <i>rs2241145</i> and <i>rs243832</i> (metalloproteinase 2 (<i>MMP2</i>)), <i>rs13925</i> and <i>rs2236416</i> (metalloproteinase 9 (<i>MMP9</i>)), and <i>rs6269</i> (cathecol-o-methyltransferase (<i>COMT</i>)) were genotyped. Data were submitted to statistical analysis with a significance level of 0.05. In adults, in univariate logistic regression, presence of caries, attrition, and use of alcohol were increased in bruxism individuals (<i>p</i> < 0.05). In addition, in adults, there was an association between bruxism and <i>MMP9</i> (<i>rs13925</i>, <i>p</i> = 0.0001) and bruxism and <i>COMT</i> (<i>rs6269</i>, <i>p</i> = 0.003). In children, a borderline association was observed for <i>MMP9</i> (<i>rs2236416</i>, <i>p</i> = 0.08). When we performed multivariate logistic regression analyses in adults, the same clinical characteristics remained associated with bruxism, and orthodontic treatment was also associated, besides <i>rs13925</i>, in the AG genotype (<i>p</i> = 0.015, OR<sub>a</sub>: 3.40 (1.27–9.07)). For the first time, we provide statistical evidence that these genes are associate with bruxism.https://www.mdpi.com/2075-4426/10/2/44biomarkerstemporomandibular disordersgeneticsmatrix metalloproteinaseschild dentistryoral diagnosis |
| spellingShingle | Alexandre R. Vieira Rafaela Scariot Jennifer T. Gerber Juliana Arid Erika C. Küchler Aline M. Sebastiani Marcelo Palinkas Kranya V. Díaz-Serrano Carolina P. Torres Simone C. H. Regalo Paulo Nelson-Filho Diego G. Bussaneli Kathleen Deeley Adriana Modesto Bruxism Throughout the Lifespan and Variants in <i>MMP2</i>, <i>MMP9</i> and <i>COMT</i> Journal of Personalized Medicine biomarkers temporomandibular disorders genetics matrix metalloproteinases child dentistry oral diagnosis |
| title | Bruxism Throughout the Lifespan and Variants in <i>MMP2</i>, <i>MMP9</i> and <i>COMT</i> |
| title_full | Bruxism Throughout the Lifespan and Variants in <i>MMP2</i>, <i>MMP9</i> and <i>COMT</i> |
| title_fullStr | Bruxism Throughout the Lifespan and Variants in <i>MMP2</i>, <i>MMP9</i> and <i>COMT</i> |
| title_full_unstemmed | Bruxism Throughout the Lifespan and Variants in <i>MMP2</i>, <i>MMP9</i> and <i>COMT</i> |
| title_short | Bruxism Throughout the Lifespan and Variants in <i>MMP2</i>, <i>MMP9</i> and <i>COMT</i> |
| title_sort | bruxism throughout the lifespan and variants in i mmp2 i i mmp9 i and i comt i |
| topic | biomarkers temporomandibular disorders genetics matrix metalloproteinases child dentistry oral diagnosis |
| url | https://www.mdpi.com/2075-4426/10/2/44 |
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