Development of curcumin liposome formulations using polyol dilution method
This study was aimed to formulate curcumin liposomes (CLs) by using polyol dilution method which is advantageous for no residue of organic solvent. CLs were the mixture of hydrogenated phosphatidylcholine (PC) and cholesterol (CH) at the molar ratio of 9:1. Propylene glycol (PG), glycerin, and pol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Prince of Songkla University
2016-12-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | http://rdo.psu.ac.th/sjstweb/journal/38-6/38-6-2.pdf |
| _version_ | 1818588984275632128 |
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| author | Lalana Kongkaneramit Porntipa Aiemsum-ang Prartana Kewsuwan |
| author_facet | Lalana Kongkaneramit Porntipa Aiemsum-ang Prartana Kewsuwan |
| author_sort | Lalana Kongkaneramit |
| collection | DOAJ |
| description | This study was aimed to formulate curcumin liposomes (CLs) by using polyol dilution method which is advantageous
for no residue of organic solvent. CLs were the mixture of hydrogenated phosphatidylcholine (PC) and cholesterol (CH) at
the molar ratio of 9:1. Propylene glycol (PG), glycerin, and polyethylene glycol 400 (PEG-400) were used as polyol solvent.
Extrusion was applied after the suspension formed. The amount of polyol and curcumin and preparing temperature were
investigated. The obtained suspensions were observed for appearance, size, size distribution, zeta potential, morphology,
and percentage of entrapment. The results showed that type and amount of polyol had an impact on both liposomal size and
the amount of entrapped curcumin, while preparing temperature was also an important factor. However, the solubility of lipids
and drug in a given polyol should be considered because of loading efficiency in the formulation. |
| first_indexed | 2024-12-16T09:33:26Z |
| format | Article |
| id | doaj.art-63887f530e21424ab868dee30422f36f |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-12-16T09:33:26Z |
| publishDate | 2016-12-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-63887f530e21424ab868dee30422f36f2022-12-21T22:36:27ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952016-12-0138660561010.14456/sjst-psu.2016.77Development of curcumin liposome formulations using polyol dilution methodLalana Kongkaneramit0Porntipa Aiemsum-ang1Prartana Kewsuwan2Department of Pharmaceutical Technology, Srinakharinwirot University, Ongkharak, Nakhon Nayok, 26120 Thailand.Department of Pharmaceutical Technology, Srinakharinwirot University, Ongkharak, Nakhon Nayok, 26120 Thailand.Nuclear Research and Developments, Thailand Institute of Nuclear Technology (Public Organization), Ongkharak, Nakhon Nayok, 26120 Thailand.This study was aimed to formulate curcumin liposomes (CLs) by using polyol dilution method which is advantageous for no residue of organic solvent. CLs were the mixture of hydrogenated phosphatidylcholine (PC) and cholesterol (CH) at the molar ratio of 9:1. Propylene glycol (PG), glycerin, and polyethylene glycol 400 (PEG-400) were used as polyol solvent. Extrusion was applied after the suspension formed. The amount of polyol and curcumin and preparing temperature were investigated. The obtained suspensions were observed for appearance, size, size distribution, zeta potential, morphology, and percentage of entrapment. The results showed that type and amount of polyol had an impact on both liposomal size and the amount of entrapped curcumin, while preparing temperature was also an important factor. However, the solubility of lipids and drug in a given polyol should be considered because of loading efficiency in the formulation.http://rdo.psu.ac.th/sjstweb/journal/38-6/38-6-2.pdfliposomespolyolcurcuminentrapmentTEM |
| spellingShingle | Lalana Kongkaneramit Porntipa Aiemsum-ang Prartana Kewsuwan Development of curcumin liposome formulations using polyol dilution method Songklanakarin Journal of Science and Technology (SJST) liposomes polyol curcumin entrapment TEM |
| title | Development of curcumin liposome formulations using polyol dilution method |
| title_full | Development of curcumin liposome formulations using polyol dilution method |
| title_fullStr | Development of curcumin liposome formulations using polyol dilution method |
| title_full_unstemmed | Development of curcumin liposome formulations using polyol dilution method |
| title_short | Development of curcumin liposome formulations using polyol dilution method |
| title_sort | development of curcumin liposome formulations using polyol dilution method |
| topic | liposomes polyol curcumin entrapment TEM |
| url | http://rdo.psu.ac.th/sjstweb/journal/38-6/38-6-2.pdf |
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