Multi‐omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer

Multi‐omic profiling reveals an RNA processing rheostat that predisposes to prostate cancer

Abstract Prostate cancer is the most commonly diagnosed malignancy and the third leading cause of cancer deaths. GWAS have identified variants associated with prostate cancer susceptibility; however, mechanistic and functional validation of these mutations is lacking. We used CRISPR‐Cas9 genome edit...

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Bibliographic Details
Main Authors: Maike Stentenbach, Judith A Ermer, Danielle L Rudler, Kara L Perks, Samuel A Raven, Richard G Lee, Tim McCubbin, Esteban Marcellin, Stefan J Siira, Oliver Rackham, Aleksandra Filipovska
Format: Article
Language:English
Published: Springer Nature 2023-06-01
Series:EMBO Molecular Medicine
Subjects:
gene expression
mitochondria
prostate cancer susceptibility
RNA processing
Online Access:https://doi.org/10.15252/emmm.202317463

Internet

https://doi.org/10.15252/emmm.202317463

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