Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors
Abstract Background The goal of this study was to evaluate the relationship between maternal 25-OH Vitamin D serum levels and neonatal early-onset sepsis in newborns by the effective factors. Methods A case-control study was done and 64 neonates hospitalized in Akbar Abadi Hospital (Tehran- Iran; 20...
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| Format: | Article |
| Language: | English |
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BMC
2019-07-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-019-1095-3 |
| _version_ | 1828782876629401600 |
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| author | Maryam Saboute Rahman Yavar Mandana Kashaki Fatemeh Kazemi Khaledi Nasrin Khalesi Farzaneh Rohani |
| author_facet | Maryam Saboute Rahman Yavar Mandana Kashaki Fatemeh Kazemi Khaledi Nasrin Khalesi Farzaneh Rohani |
| author_sort | Maryam Saboute |
| collection | DOAJ |
| description | Abstract Background The goal of this study was to evaluate the relationship between maternal 25-OH Vitamin D serum levels and neonatal early-onset sepsis in newborns by the effective factors. Methods A case-control study was done and 64 neonates hospitalized in Akbar Abadi Hospital (Tehran- Iran; 2016) and their mothers were enrolled. The case group consisted of 32 NICU term hospitalized neonates due to neonatal early-onset sepsis. Thirty-two term newborns that referred to hospital for rule out hyperbilirubinemia during the first 72 h of life were also considered as the control. Results Sixty- four mothers with mean age 28.76 ± 6.60 years and mean gestational age 39.64 ± 1.62 weeks entered the study. There was a significant correlation between sepsis and older age of mothers and low Apgar score (P-value = 0.02, 0.01 respectively). The maternal vitamin D serum level was reversely correlated with neonatal sepsis occurrence (P-value = 0.03). There was a significant correlation between maternal vitamin D supplement intake during pregnancy and lower risk for neonatal sepsis (P-value = 0.003). Conclusion The level of maternal serum Vitamin D was inversely correlated with neonatal sepsis occurrence and intake of vitamin D supplement during pregnancy could decrease the risk of early neonatal sepsis. |
| first_indexed | 2024-12-11T17:55:12Z |
| format | Article |
| id | doaj.art-638c1a8acd94480ca8a01070ef5c3b75 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-11T17:55:12Z |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-638c1a8acd94480ca8a01070ef5c3b752022-12-22T00:56:04ZengBMCLipids in Health and Disease1476-511X2019-07-011811610.1186/s12944-019-1095-3Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factorsMaryam Saboute0Rahman Yavar1Mandana Kashaki2Fatemeh Kazemi Khaledi3Nasrin Khalesi4Farzaneh Rohani5Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS)Department of genetics, Akbarabadi Hospital, Iran University of Medical SciencesShahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS)Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS)Department of Pediatrics, Ali Asghar Hospital, Iran University of Medical SciencesPediatric Growth and Development Research Center, Iran University of Medical SciencesAbstract Background The goal of this study was to evaluate the relationship between maternal 25-OH Vitamin D serum levels and neonatal early-onset sepsis in newborns by the effective factors. Methods A case-control study was done and 64 neonates hospitalized in Akbar Abadi Hospital (Tehran- Iran; 2016) and their mothers were enrolled. The case group consisted of 32 NICU term hospitalized neonates due to neonatal early-onset sepsis. Thirty-two term newborns that referred to hospital for rule out hyperbilirubinemia during the first 72 h of life were also considered as the control. Results Sixty- four mothers with mean age 28.76 ± 6.60 years and mean gestational age 39.64 ± 1.62 weeks entered the study. There was a significant correlation between sepsis and older age of mothers and low Apgar score (P-value = 0.02, 0.01 respectively). The maternal vitamin D serum level was reversely correlated with neonatal sepsis occurrence (P-value = 0.03). There was a significant correlation between maternal vitamin D supplement intake during pregnancy and lower risk for neonatal sepsis (P-value = 0.003). Conclusion The level of maternal serum Vitamin D was inversely correlated with neonatal sepsis occurrence and intake of vitamin D supplement during pregnancy could decrease the risk of early neonatal sepsis.http://link.springer.com/article/10.1186/s12944-019-1095-3MaternalVitamin DNeonatal early onset sepsisVitamin D supplementApgar score |
| spellingShingle | Maryam Saboute Rahman Yavar Mandana Kashaki Fatemeh Kazemi Khaledi Nasrin Khalesi Farzaneh Rohani Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors Lipids in Health and Disease Maternal Vitamin D Neonatal early onset sepsis Vitamin D supplement Apgar score |
| title | Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors |
| title_full | Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors |
| title_fullStr | Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors |
| title_full_unstemmed | Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors |
| title_short | Investigation of association between maternal 25-OH vitamin D serum levels and neonatal early onset sepsis in newborns by evaluating key factors |
| title_sort | investigation of association between maternal 25 oh vitamin d serum levels and neonatal early onset sepsis in newborns by evaluating key factors |
| topic | Maternal Vitamin D Neonatal early onset sepsis Vitamin D supplement Apgar score |
| url | http://link.springer.com/article/10.1186/s12944-019-1095-3 |
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