Neurological disorders associated with COVID-19 in Sri Lanka
Abstract Background Neurological manifestations of SARS-CoV-2 infection have been reported from many countries around the world, including the South Asian region. This surveillance study aimed to describe the spectrum of neurological disorders associated with COVID-19 in Sri Lanka. Methods COVID-19...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03399-w |
| _version_ | 1797558874356580352 |
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| author | Thashi Chang Ruwani Wijeyekoon Ajantha Keshavaraj Udaya Ranawaka Sunethra Senanayake Pyara Ratnayake Bimsara Senanayake Manjula C. Caldera Gamini Pathirana Darshana Sirisena Jithangi Wanigasinghe Saman Gunatilake on behalf of the ASN COVID-19 Study Group |
| author_facet | Thashi Chang Ruwani Wijeyekoon Ajantha Keshavaraj Udaya Ranawaka Sunethra Senanayake Pyara Ratnayake Bimsara Senanayake Manjula C. Caldera Gamini Pathirana Darshana Sirisena Jithangi Wanigasinghe Saman Gunatilake on behalf of the ASN COVID-19 Study Group |
| author_sort | Thashi Chang |
| collection | DOAJ |
| description | Abstract Background Neurological manifestations of SARS-CoV-2 infection have been reported from many countries around the world, including the South Asian region. This surveillance study aimed to describe the spectrum of neurological disorders associated with COVID-19 in Sri Lanka. Methods COVID-19 patients manifesting neurological disorders one week prior and up to six weeks after infection were recruited from all the neurology centres of the government hospitals in Sri Lanka from May 2021 – May 2022. Data was collected using a structured data form that was electronically transmitted to a central repository. All patients were evaluated and managed by a neurologist. Data were analysed using simple descriptive analysis to characterise demographic and disease related variables, and simple comparisons and logistic regression were performed to analyse outcomes and their associations. Results One hundred and eighty-four patients with neurological manifestations associated with COVID-19 were recruited from all nine provinces in Sri Lanka. Ischaemic stroke (31%) was the commonest neurological manifestation followed by encephalopathy (13.6%), Guillain–Barre syndrome (GBS) (9.2%) and encephalitis (7.6%). Ischaemic stroke, encephalitis and encephalopathy presented within 6 days of onset of COVID-19 symptoms, whereas GBS and myelitis presented up to 10 days post onset while epilepsy and Bell palsy presented up to 20 – 40 days post onset. Haemorrhagic stroke presented either just prior to or at onset, or 10 – 25 days post onset of COVID-19 symptomatic infection. An increased frequency of children presenting with encephalitis and encephalopathy was observed during the Omicron variant predominant period. A poor outcome (no recovery or death) was associated with supplemental oxygen requirement during admission (Odds Ratio: 12.94; p = 0.046). Conclusions The spectrum and frequencies of COVID-19 associated neurological disorders in Sri Lanka were similar to that reported from other countries, with strokes and encephalopathy being the commonest. Requiring supplemental oxygen during hospitalisation was associated with a poor outcome. |
| first_indexed | 2024-03-10T17:37:31Z |
| format | Article |
| id | doaj.art-638c364bbb2840adbe588efd21dc6ef2 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-10T17:37:31Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-638c364bbb2840adbe588efd21dc6ef22023-11-20T09:48:52ZengBMCBMC Neurology1471-23772023-10-0123111010.1186/s12883-023-03399-wNeurological disorders associated with COVID-19 in Sri LankaThashi Chang0Ruwani Wijeyekoon1Ajantha Keshavaraj2Udaya Ranawaka3Sunethra Senanayake4Pyara Ratnayake5Bimsara Senanayake6Manjula C. Caldera7Gamini Pathirana8Darshana Sirisena9Jithangi Wanigasinghe10Saman Gunatilake11on behalf of the ASN COVID-19 Study GroupDepartment of Clinical Medicine, Faculty of Medicine, University of ColomboAssociation of Sri Lankan NeurologistsTeaching Hospital JaffnaDepartment of Medicine, Faculty of Medicine, University of KelaniyaNational Hospital of Sri LankaLady Ridgeway Hospital for ChildrenNational Hospital of Sri LankaTeaching Hospital AnuradhapuraNational Hospital of Sri LankaColombo North Teaching HospitalDepartment of Paediatrics, Faculty of Medicine, University of ColomboDepartment of Medicine, University of Sri JayewardenepuraAbstract Background Neurological manifestations of SARS-CoV-2 infection have been reported from many countries around the world, including the South Asian region. This surveillance study aimed to describe the spectrum of neurological disorders associated with COVID-19 in Sri Lanka. Methods COVID-19 patients manifesting neurological disorders one week prior and up to six weeks after infection were recruited from all the neurology centres of the government hospitals in Sri Lanka from May 2021 – May 2022. Data was collected using a structured data form that was electronically transmitted to a central repository. All patients were evaluated and managed by a neurologist. Data were analysed using simple descriptive analysis to characterise demographic and disease related variables, and simple comparisons and logistic regression were performed to analyse outcomes and their associations. Results One hundred and eighty-four patients with neurological manifestations associated with COVID-19 were recruited from all nine provinces in Sri Lanka. Ischaemic stroke (31%) was the commonest neurological manifestation followed by encephalopathy (13.6%), Guillain–Barre syndrome (GBS) (9.2%) and encephalitis (7.6%). Ischaemic stroke, encephalitis and encephalopathy presented within 6 days of onset of COVID-19 symptoms, whereas GBS and myelitis presented up to 10 days post onset while epilepsy and Bell palsy presented up to 20 – 40 days post onset. Haemorrhagic stroke presented either just prior to or at onset, or 10 – 25 days post onset of COVID-19 symptomatic infection. An increased frequency of children presenting with encephalitis and encephalopathy was observed during the Omicron variant predominant period. A poor outcome (no recovery or death) was associated with supplemental oxygen requirement during admission (Odds Ratio: 12.94; p = 0.046). Conclusions The spectrum and frequencies of COVID-19 associated neurological disorders in Sri Lanka were similar to that reported from other countries, with strokes and encephalopathy being the commonest. Requiring supplemental oxygen during hospitalisation was associated with a poor outcome.https://doi.org/10.1186/s12883-023-03399-wCOVID-19SARS-CoV-2NeurologySri Lanka |
| spellingShingle | Thashi Chang Ruwani Wijeyekoon Ajantha Keshavaraj Udaya Ranawaka Sunethra Senanayake Pyara Ratnayake Bimsara Senanayake Manjula C. Caldera Gamini Pathirana Darshana Sirisena Jithangi Wanigasinghe Saman Gunatilake on behalf of the ASN COVID-19 Study Group Neurological disorders associated with COVID-19 in Sri Lanka BMC Neurology COVID-19 SARS-CoV-2 Neurology Sri Lanka |
| title | Neurological disorders associated with COVID-19 in Sri Lanka |
| title_full | Neurological disorders associated with COVID-19 in Sri Lanka |
| title_fullStr | Neurological disorders associated with COVID-19 in Sri Lanka |
| title_full_unstemmed | Neurological disorders associated with COVID-19 in Sri Lanka |
| title_short | Neurological disorders associated with COVID-19 in Sri Lanka |
| title_sort | neurological disorders associated with covid 19 in sri lanka |
| topic | COVID-19 SARS-CoV-2 Neurology Sri Lanka |
| url | https://doi.org/10.1186/s12883-023-03399-w |
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