A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma
Lung adenocarcinoma (LUAD) has become the most prevalent histologic subset of primary lung cancer, and effective innovative prognostic models are needed to enhance the feasibility of targeted therapies for the disease. Programmed cell death (PCD) performs an integral function in the origin and treat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.975185/full |
| _version_ | 1798039988786429952 |
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| author | Huizhe Zhang Yanchen Shi Qing Yi Cong Wang Qingqing Xia Yufeng Zhang Weilong Jiang Jia Qi |
| author_facet | Huizhe Zhang Yanchen Shi Qing Yi Cong Wang Qingqing Xia Yufeng Zhang Weilong Jiang Jia Qi |
| author_sort | Huizhe Zhang |
| collection | DOAJ |
| description | Lung adenocarcinoma (LUAD) has become the most prevalent histologic subset of primary lung cancer, and effective innovative prognostic models are needed to enhance the feasibility of targeted therapies for the disease. Programmed cell death (PCD) performs an integral function in the origin and treatment of cancer. Some PCD-related effective signatures for predicting prognosis in LUAD patients could provide potential therapeutic options in LUAD. A copper-dependent cell death referred to as cuproptosis is distinct from known PCD. However, whether cuproptosis is associated with LUAD patients' prognoses and the potential roles of cuproptosis-related genes involved is still unknown. For the prediction of LUAD prognosis, we developed a unique cuproptosis-associated gene signature. In The Cancer Genome Atlas (TCGA) cohort, the score derived from the risk signature on the basis of six cuproptosis-related genes was found to independently serve as a risk factor for anticipating lung cancer-related death. The differentially expressed genes between the high- and low-risk groups were linked to the cilium-related function. LUAD patients’ prognoses may now be predicted by a unique gene signature identified in this work. This discovery also provides a substantial foundation for future research into the links between cuproptosis-associated genes and cilium-related function in LUAD patients. |
| first_indexed | 2024-04-11T22:01:18Z |
| format | Article |
| id | doaj.art-638cdd98b899454eac25770cde231132 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-11T22:01:18Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-638cdd98b899454eac25770cde2311322022-12-22T04:00:55ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-08-011310.3389/fgene.2022.975185975185A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinomaHuizhe Zhang0Yanchen Shi1Qing Yi2Cong Wang3Qingqing Xia4Yufeng Zhang5Weilong Jiang6Jia Qi7Department of Respiratory Medicine, Yancheng Hospital of Traditional Chinese Medicine, Yancheng Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, ChinaDepartment of Pulmonary and Critical Care Medicine, Traditional Chinese and Western Medicine Clinical College of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Pulmonary and Critical Care Medicine, Traditional Chinese and Western Medicine Clinical College of Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Pulmonary and Critical Care Medicine, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin, ChinaDepartment of Pulmonary and Critical Care Medicine, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin, ChinaDepartment of Pulmonary and Critical Care Medicine, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin, ChinaDepartment of Pulmonary and Critical Care Medicine, Jiangyin Hospital of Traditional Chinese Medicine, Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin, ChinaDepartment of Pharmacy, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaLung adenocarcinoma (LUAD) has become the most prevalent histologic subset of primary lung cancer, and effective innovative prognostic models are needed to enhance the feasibility of targeted therapies for the disease. Programmed cell death (PCD) performs an integral function in the origin and treatment of cancer. Some PCD-related effective signatures for predicting prognosis in LUAD patients could provide potential therapeutic options in LUAD. A copper-dependent cell death referred to as cuproptosis is distinct from known PCD. However, whether cuproptosis is associated with LUAD patients' prognoses and the potential roles of cuproptosis-related genes involved is still unknown. For the prediction of LUAD prognosis, we developed a unique cuproptosis-associated gene signature. In The Cancer Genome Atlas (TCGA) cohort, the score derived from the risk signature on the basis of six cuproptosis-related genes was found to independently serve as a risk factor for anticipating lung cancer-related death. The differentially expressed genes between the high- and low-risk groups were linked to the cilium-related function. LUAD patients’ prognoses may now be predicted by a unique gene signature identified in this work. This discovery also provides a substantial foundation for future research into the links between cuproptosis-associated genes and cilium-related function in LUAD patients.https://www.frontiersin.org/articles/10.3389/fgene.2022.975185/fullgene signaturecuproptosisprognosislung adenocarcinomacilium |
| spellingShingle | Huizhe Zhang Yanchen Shi Qing Yi Cong Wang Qingqing Xia Yufeng Zhang Weilong Jiang Jia Qi A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma Frontiers in Genetics gene signature cuproptosis prognosis lung adenocarcinoma cilium |
| title | A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma |
| title_full | A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma |
| title_fullStr | A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma |
| title_full_unstemmed | A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma |
| title_short | A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma |
| title_sort | novel defined cuproptosis related gene signature for predicting the prognosis of lung adenocarcinoma |
| topic | gene signature cuproptosis prognosis lung adenocarcinoma cilium |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.975185/full |
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