High Effectiveness of SARS-CoV-2 Vaccines in Reducing COVID-19-Related Deaths in over 75-Year-Olds, Ceará State, Brazil
In Brazil, the SARS-CoV-2 vaccination program has so far prioritized people over 75 years of age. By the end of March 2021, in Ceará State, a total of 313,328 elderly people had received at least one dose of vaccine (45% Oxford-AstraZeneca/Fiocruz and 55% CoronaVac-Sinovac/Butantan), and 159,970 had...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/6/3/129 |
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| author | Carlos Henrique Alencar Luciano Pamplona de Góes Cavalcanti Magda Moura de Almeida Patrícia Pereira Lima Barbosa Kellyn Kessiene de Sousa Cavalcante Déborah Nunes de Melo Bruno Cavalcante Fales de Brito Alves Jorg Heukelbach |
| author_facet | Carlos Henrique Alencar Luciano Pamplona de Góes Cavalcanti Magda Moura de Almeida Patrícia Pereira Lima Barbosa Kellyn Kessiene de Sousa Cavalcante Déborah Nunes de Melo Bruno Cavalcante Fales de Brito Alves Jorg Heukelbach |
| author_sort | Carlos Henrique Alencar |
| collection | DOAJ |
| description | In Brazil, the SARS-CoV-2 vaccination program has so far prioritized people over 75 years of age. By the end of March 2021, in Ceará State, a total of 313,328 elderly people had received at least one dose of vaccine (45% Oxford-AstraZeneca/Fiocruz and 55% CoronaVac-Sinovac/Butantan), and 159,970 had received two doses (83% CoronaVac-Sinovac/Butantan and 17% Oxford-AstraZeneca/Fiocruz). After a single dose, there was already a significant reduction in COVID 19-related deaths (protection ratio: 19.31 (95% CI: 18.20–20.48), attributable protection ratio: 94.8%); higher protection ratios were observed after the application of two doses of the vaccine (132.67; 95% CI: 109.88–160.18), with an attributable protection ratio of 99.2%. SARS-CoV-2 vaccines are highly effective in reducing the number of COVID-19-related deaths in over 75-year-olds in Brazil, one of the hardest hit countries by the current pandemic. |
| first_indexed | 2024-03-10T07:09:37Z |
| format | Article |
| id | doaj.art-638d2f9d2b0940be996e47e26374acaf |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T07:09:37Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-638d2f9d2b0940be996e47e26374acaf2023-11-22T15:32:07ZengMDPI AGTropical Medicine and Infectious Disease2414-63662021-07-016312910.3390/tropicalmed6030129High Effectiveness of SARS-CoV-2 Vaccines in Reducing COVID-19-Related Deaths in over 75-Year-Olds, Ceará State, BrazilCarlos Henrique Alencar0Luciano Pamplona de Góes Cavalcanti1Magda Moura de Almeida2Patrícia Pereira Lima Barbosa3Kellyn Kessiene de Sousa Cavalcante4Déborah Nunes de Melo5Bruno Cavalcante Fales de Brito Alves6Jorg Heukelbach7School of Medicine, Post Graduate Program in Public Health, Federal University of Ceará, Fortaleza 60430-140, BrazilSchool of Medicine, Post Graduate Program in Public Health, Federal University of Ceará, Fortaleza 60430-140, BrazilSchool of Medicine, Post Graduate Program in Public Health, Federal University of Ceará, Fortaleza 60430-140, BrazilSchool of Medicine, Post Graduate Program in Public Health, Federal University of Ceará, Fortaleza 60430-140, BrazilSchool of Medicine, Post Graduate Program in Public Health, Federal University of Ceará, Fortaleza 60430-140, BrazilSchool of Medicine, Post Graduate Program in Public Health, Federal University of Ceará, Fortaleza 60430-140, BrazilChristus University Center, Fortaleza 60190-180, BrazilSchool of Medicine, Post Graduate Program in Public Health, Federal University of Ceará, Fortaleza 60430-140, BrazilIn Brazil, the SARS-CoV-2 vaccination program has so far prioritized people over 75 years of age. By the end of March 2021, in Ceará State, a total of 313,328 elderly people had received at least one dose of vaccine (45% Oxford-AstraZeneca/Fiocruz and 55% CoronaVac-Sinovac/Butantan), and 159,970 had received two doses (83% CoronaVac-Sinovac/Butantan and 17% Oxford-AstraZeneca/Fiocruz). After a single dose, there was already a significant reduction in COVID 19-related deaths (protection ratio: 19.31 (95% CI: 18.20–20.48), attributable protection ratio: 94.8%); higher protection ratios were observed after the application of two doses of the vaccine (132.67; 95% CI: 109.88–160.18), with an attributable protection ratio of 99.2%. SARS-CoV-2 vaccines are highly effective in reducing the number of COVID-19-related deaths in over 75-year-olds in Brazil, one of the hardest hit countries by the current pandemic.https://www.mdpi.com/2414-6366/6/3/129COVID-19SARS-CoV-2COVID-19 vaccinesmortalityepidemiologypublic health |
| spellingShingle | Carlos Henrique Alencar Luciano Pamplona de Góes Cavalcanti Magda Moura de Almeida Patrícia Pereira Lima Barbosa Kellyn Kessiene de Sousa Cavalcante Déborah Nunes de Melo Bruno Cavalcante Fales de Brito Alves Jorg Heukelbach High Effectiveness of SARS-CoV-2 Vaccines in Reducing COVID-19-Related Deaths in over 75-Year-Olds, Ceará State, Brazil Tropical Medicine and Infectious Disease COVID-19 SARS-CoV-2 COVID-19 vaccines mortality epidemiology public health |
| title | High Effectiveness of SARS-CoV-2 Vaccines in Reducing COVID-19-Related Deaths in over 75-Year-Olds, Ceará State, Brazil |
| title_full | High Effectiveness of SARS-CoV-2 Vaccines in Reducing COVID-19-Related Deaths in over 75-Year-Olds, Ceará State, Brazil |
| title_fullStr | High Effectiveness of SARS-CoV-2 Vaccines in Reducing COVID-19-Related Deaths in over 75-Year-Olds, Ceará State, Brazil |
| title_full_unstemmed | High Effectiveness of SARS-CoV-2 Vaccines in Reducing COVID-19-Related Deaths in over 75-Year-Olds, Ceará State, Brazil |
| title_short | High Effectiveness of SARS-CoV-2 Vaccines in Reducing COVID-19-Related Deaths in over 75-Year-Olds, Ceará State, Brazil |
| title_sort | high effectiveness of sars cov 2 vaccines in reducing covid 19 related deaths in over 75 year olds ceara state brazil |
| topic | COVID-19 SARS-CoV-2 COVID-19 vaccines mortality epidemiology public health |
| url | https://www.mdpi.com/2414-6366/6/3/129 |
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