Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting
Methodological approaches developed at Research Institute of Clinical and Experimental Lymphology for a number of years allow formulating the importance of embedding active pharmaceutical ingredients (API) in the structure of porous carriers (sorbents). The composition of the carrier and API is an e...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2020-05-01
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| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/370 |
| _version_ | 1826575759156707328 |
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| author | M. A. Korolev L. N. Rachkovskaya V. I. Konenkov A. Yu. Letyagin P. G. Madonov |
| author_facet | M. A. Korolev L. N. Rachkovskaya V. I. Konenkov A. Yu. Letyagin P. G. Madonov |
| author_sort | M. A. Korolev |
| collection | DOAJ |
| description | Methodological approaches developed at Research Institute of Clinical and Experimental Lymphology for a number of years allow formulating the importance of embedding active pharmaceutical ingredients (API) in the structure of porous carriers (sorbents). The composition of the carrier and API is an enteral system for prolonged dosing of pharmacological agents, which allows providing a specific pharmacological effect and safety of use. The pores of the media (sorbents) act as containers for API. This is especially important for rapidly absorbed drugs, which include, for example, lithium preparations that are used in narrow concentration limits due to their side effects. At the moment, an innovative technology for creating new medicines with an improved combination of efficiency and safety (pharmacological upgrade) has been developed and implemented. The essence of the technology is to create a composition of aluminum oxide and polydimethylsiloxane (matrix) and an active pharmacological ingredient (API). A study of two drugs based on matrix / lithium citrate and matrix / melatonin showed continued specific pharmacological activity of API, better pharmacokinetics, and better safety parameters. The matrix of aluminum oxide and polydimethylsiloxane provides an upgrade of the pharmacological properties of drugs for the dosed and safe delivery of API to the zone of their therapeutic effect. |
| first_indexed | 2024-03-08T14:33:58Z |
| format | Article |
| id | doaj.art-638d73707a5e405386db1692157d5470 |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2025-03-14T13:19:48Z |
| publishDate | 2020-05-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-638d73707a5e405386db1692157d54702025-02-28T13:43:55ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202020-05-01402404610.15372/SSMJ20200205254Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targetingM. A. Korolev0L. N. Rachkovskaya1V. I. Konenkov2A. Yu. Letyagin3P. G. Madonov4Research Institute of Clinical and Experimental Lymphology Branch of the Institute of Cytology and Genetics, SB RASResearch Institute of Clinical and Experimental Lymphology Branch of the Institute of Cytology and Genetics, SB RASResearch Institute of Clinical and Experimental Lymphology Branch of the Institute of Cytology and Genetics, SB RASResearch Institute of Clinical and Experimental Lymphology Branch of the Institute of Cytology and Genetics, SB RASResearch Institute of Clinical and Experimental Lymphology Branch of the Institute of Cytology and Genetics, SB RASMethodological approaches developed at Research Institute of Clinical and Experimental Lymphology for a number of years allow formulating the importance of embedding active pharmaceutical ingredients (API) in the structure of porous carriers (sorbents). The composition of the carrier and API is an enteral system for prolonged dosing of pharmacological agents, which allows providing a specific pharmacological effect and safety of use. The pores of the media (sorbents) act as containers for API. This is especially important for rapidly absorbed drugs, which include, for example, lithium preparations that are used in narrow concentration limits due to their side effects. At the moment, an innovative technology for creating new medicines with an improved combination of efficiency and safety (pharmacological upgrade) has been developed and implemented. The essence of the technology is to create a composition of aluminum oxide and polydimethylsiloxane (matrix) and an active pharmacological ingredient (API). A study of two drugs based on matrix / lithium citrate and matrix / melatonin showed continued specific pharmacological activity of API, better pharmacokinetics, and better safety parameters. The matrix of aluminum oxide and polydimethylsiloxane provides an upgrade of the pharmacological properties of drugs for the dosed and safe delivery of API to the zone of their therapeutic effect.https://sibmed.elpub.ru/jour/article/view/370aluminum oxidepolydimethylsiloxanelithium compositionspharmacological upgrade |
| spellingShingle | M. A. Korolev L. N. Rachkovskaya V. I. Konenkov A. Yu. Letyagin P. G. Madonov Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting Сибирский научный медицинский журнал aluminum oxide polydimethylsiloxane lithium compositions pharmacological upgrade |
| title | Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting |
| title_full | Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting |
| title_fullStr | Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting |
| title_full_unstemmed | Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting |
| title_short | Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting |
| title_sort | composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting |
| topic | aluminum oxide polydimethylsiloxane lithium compositions pharmacological upgrade |
| url | https://sibmed.elpub.ru/jour/article/view/370 |
| work_keys_str_mv | AT makorolev compositionbasedonaluminumoxideandpolydimethylsiloxanematrixforenhancingdrugtargeting AT lnrachkovskaya compositionbasedonaluminumoxideandpolydimethylsiloxanematrixforenhancingdrugtargeting AT vikonenkov compositionbasedonaluminumoxideandpolydimethylsiloxanematrixforenhancingdrugtargeting AT ayuletyagin compositionbasedonaluminumoxideandpolydimethylsiloxanematrixforenhancingdrugtargeting AT pgmadonov compositionbasedonaluminumoxideandpolydimethylsiloxanematrixforenhancingdrugtargeting |