Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria.

Plasma uric acid levels correlate with inflammation and disease severity in Malian children with Plasmodium falciparum malaria.

Plasmodium falciparum elicits host inflammatory responses that cause the symptoms and severe manifestations of malaria. One proposed mechanism involves formation of immunostimulatory uric acid (UA) precipitates, which are released from sequestered schizonts into microvessels. Another involves hypoxa...

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Bibliographic Details
Main Authors: Tatiana M Lopera-Mesa, Neida K Mita-Mendoza, Diana L van de Hoef, Saibou Doumbia, Drissa Konaté, Mory Doumbouya, Wenjuan Gu, Karim Traoré, Seidina A S Diakité, Alan T Remaley, Jennifer M Anderson, Ana Rodriguez, Michael P Fay, Carole A Long, Mahamadou Diakité, Rick M Fairhurst
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3465329?pdf=render

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