Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory
Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that transmissible cancers are infrequent because a precise confluenc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/2/241 |
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| author | Sophie Tissot Anne-Lise Gérard Justine Boutry Antoine M. Dujon Tracey Russel Hannah Siddle Aurélie Tasiemski Jordan Meliani Rodrigo Hamede Benjamin Roche Beata Ujvari Frédéric Thomas |
| author_facet | Sophie Tissot Anne-Lise Gérard Justine Boutry Antoine M. Dujon Tracey Russel Hannah Siddle Aurélie Tasiemski Jordan Meliani Rodrigo Hamede Benjamin Roche Beata Ujvari Frédéric Thomas |
| author_sort | Sophie Tissot |
| collection | DOAJ |
| description | Although the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that transmissible cancers are infrequent because a precise confluence of tumor and host traits is required for their emergence. This explanation is plausible as transmissible cancers, like all emerging pathogens, will need specific biotic and abiotic conditions to be able to not only emerge, but to spread to detectable levels. Because those conditions would be rarely met, transmissible cancers would rarely spread, and thus most of the time disappear, even though they would regularly appear. Thus, further research is needed to identify the most important factors that can facilitate or block the emergence of transmissible cancers and influence their evolution. Such investigations are particularly relevant given that human activities are increasingly encroaching into wild areas, altering ecosystems and their processes, which can influence the conditions needed for the emergence and spread of transmissible cell lines. |
| first_indexed | 2024-03-09T21:16:54Z |
| format | Article |
| id | doaj.art-638ef06d4e5b4409a7dd72c211bc9cda |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T21:16:54Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-638ef06d4e5b4409a7dd72c211bc9cda2023-11-23T21:32:35ZengMDPI AGPathogens2076-08172022-02-0111224110.3390/pathogens11020241Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” TheorySophie Tissot0Anne-Lise Gérard1Justine Boutry2Antoine M. Dujon3Tracey Russel4Hannah Siddle5Aurélie Tasiemski6Jordan Meliani7Rodrigo Hamede8Benjamin Roche9Beata Ujvari10Frédéric Thomas11CREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, FranceCREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, FranceCREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, FranceCentre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 32020, AustraliaSchool of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, AustraliaSchool of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UKUniversité de Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité de Lille, 59000 Lille, FranceCREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, FranceSchool of Natural Sciences, University of Tasmania, Hobart, TAS 7001, AustraliaCREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, FranceCentre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 32020, AustraliaCREEC/MIVEGEC, Université de Montpellier, CNRS, IRD, 34394 Montpellier, FranceAlthough the true prevalence of transmissible cancers is not known, these atypical malignancies are likely rare in the wild. The reasons behind this rarity are only partially understood, but the “Perfect Storm hypothesis” suggests that transmissible cancers are infrequent because a precise confluence of tumor and host traits is required for their emergence. This explanation is plausible as transmissible cancers, like all emerging pathogens, will need specific biotic and abiotic conditions to be able to not only emerge, but to spread to detectable levels. Because those conditions would be rarely met, transmissible cancers would rarely spread, and thus most of the time disappear, even though they would regularly appear. Thus, further research is needed to identify the most important factors that can facilitate or block the emergence of transmissible cancers and influence their evolution. Such investigations are particularly relevant given that human activities are increasingly encroaching into wild areas, altering ecosystems and their processes, which can influence the conditions needed for the emergence and spread of transmissible cell lines.https://www.mdpi.com/2076-0817/11/2/241transmissible cancersenvironmental factorshuman activitiestransmissionevolutionecology |
| spellingShingle | Sophie Tissot Anne-Lise Gérard Justine Boutry Antoine M. Dujon Tracey Russel Hannah Siddle Aurélie Tasiemski Jordan Meliani Rodrigo Hamede Benjamin Roche Beata Ujvari Frédéric Thomas Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory Pathogens transmissible cancers environmental factors human activities transmission evolution ecology |
| title | Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
| title_full | Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
| title_fullStr | Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
| title_full_unstemmed | Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
| title_short | Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the “Perfect Storm” Theory |
| title_sort | transmissible cancer evolution the under estimated role of environmental factors in the perfect storm theory |
| topic | transmissible cancers environmental factors human activities transmission evolution ecology |
| url | https://www.mdpi.com/2076-0817/11/2/241 |
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