Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders
Neurodegenerative disorders are those which affect cognitive functions. Misfolding of proteins especially apolipoprotein E is a key genetic factor involved in several cognitive impairments. Increasing evidence also described the toxic effects of metals, generated by both nature and humans, on the d...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Razi Vaccine and Serum Research Institute
2022-02-01
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| Series: | Archives of Razi Institute |
| Subjects: | |
| Online Access: | https://archrazi.areeo.ac.ir/article_125925_16aea8a2a734d2fbb2b5447a0d87c131.pdf |
| _version_ | 1818236504540971008 |
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| author | A Gasmi A Menzel S Piscopo S Noor |
| author_facet | A Gasmi A Menzel S Piscopo S Noor |
| author_sort | A Gasmi |
| collection | DOAJ |
| description | Neurodegenerative disorders are those which affect cognitive functions. Misfolding of proteins especially apolipoprotein E is a key genetic factor involved in several cognitive impairments. Increasing evidence also described the toxic effects of metals, generated by both nature and humans, on the development of neurological disorders. Understanding of interaction between toxic metals and apolipoprotein E protein in cognitive decline diosrders would provide alternative treatment options. Google Scholar and PubMed database were used to search the articles using different search terms like ‘toxic metals’, ‘cognitive decline’, ‘Apolipoprotein E’, “neurodegenerative disorders” and “metals neurotoxicity”. Only those papers were included that discussed the metal exposure-apolipoprotein association in the development of cognitive decline disorders. Heavy metals are particularly recognized as a major source of neurotoxicity. These toxic metals can interact with genetic factors and play important role in disease etiology. Understanding the underlying mechanism of this interaction could provide tremendous benefits to treat cognitive decline disorders. In this study, the role of the apolipoprotein E4 gene in the development of cognitive disease conditions and their phenotypes has been discussed thoroughly which leads to the accumulation of amyloid-beta fibrils. This exploratory study revealed novel hypothetical findings which might contribute to the understanding of the neurotoxic effects of chronic toxic metals exposure and possibly improve our knowledge on the molecular mechanisms linking metal exposure to cognitive decline disorder risk. |
| first_indexed | 2024-12-12T12:10:55Z |
| format | Article |
| id | doaj.art-638f52e228f6448ab7c81b5aad08438f |
| institution | Directory Open Access Journal |
| issn | 0365-3439 2008-9872 |
| language | English |
| last_indexed | 2024-12-12T12:10:55Z |
| publishDate | 2022-02-01 |
| publisher | Razi Vaccine and Serum Research Institute |
| record_format | Article |
| series | Archives of Razi Institute |
| spelling | doaj.art-638f52e228f6448ab7c81b5aad08438f2022-12-22T00:24:54ZengRazi Vaccine and Serum Research InstituteArchives of Razi Institute0365-34392008-98722022-02-0177111010.22092/ari.2021.356078.1771125925Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline DisordersA Gasmi0A Menzel1S Piscopo2S Noor3Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, FranceLaboratoires Réunis, Junglinster, LuxembourgSociété Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, FranceInstitute of Molecular Biology and Biotechnology, Bahauddin Zakariya University Multan, PakistanNeurodegenerative disorders are those which affect cognitive functions. Misfolding of proteins especially apolipoprotein E is a key genetic factor involved in several cognitive impairments. Increasing evidence also described the toxic effects of metals, generated by both nature and humans, on the development of neurological disorders. Understanding of interaction between toxic metals and apolipoprotein E protein in cognitive decline diosrders would provide alternative treatment options. Google Scholar and PubMed database were used to search the articles using different search terms like ‘toxic metals’, ‘cognitive decline’, ‘Apolipoprotein E’, “neurodegenerative disorders” and “metals neurotoxicity”. Only those papers were included that discussed the metal exposure-apolipoprotein association in the development of cognitive decline disorders. Heavy metals are particularly recognized as a major source of neurotoxicity. These toxic metals can interact with genetic factors and play important role in disease etiology. Understanding the underlying mechanism of this interaction could provide tremendous benefits to treat cognitive decline disorders. In this study, the role of the apolipoprotein E4 gene in the development of cognitive disease conditions and their phenotypes has been discussed thoroughly which leads to the accumulation of amyloid-beta fibrils. This exploratory study revealed novel hypothetical findings which might contribute to the understanding of the neurotoxic effects of chronic toxic metals exposure and possibly improve our knowledge on the molecular mechanisms linking metal exposure to cognitive decline disorder risk.https://archrazi.areeo.ac.ir/article_125925_16aea8a2a734d2fbb2b5447a0d87c131.pdftoxic metalsbrainapolipoprotein eneurodegenerative disordersalzheimer’s disease |
| spellingShingle | A Gasmi A Menzel S Piscopo S Noor Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders Archives of Razi Institute toxic metals brain apolipoprotein e neurodegenerative disorders alzheimer’s disease |
| title | Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders |
| title_full | Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders |
| title_fullStr | Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders |
| title_full_unstemmed | Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders |
| title_short | Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders |
| title_sort | toxic metals exposure and apoe4 gene variant in cognitive decline disorders |
| topic | toxic metals brain apolipoprotein e neurodegenerative disorders alzheimer’s disease |
| url | https://archrazi.areeo.ac.ir/article_125925_16aea8a2a734d2fbb2b5447a0d87c131.pdf |
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