Inflammatory Biomarkers Aid in Diagnosis of Dementia
Dual pathology of Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID) commonly are found together at autopsy, but mixed dementia (MX) is difficult to diagnose during life. Biological criteria to diagnose AD have been defined, but are not available for vascular disease...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.717344/full |
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| author | Erik B. Erhardt John C. Adair John C. Adair Janice E. Knoefel Janice E. Knoefel Arvind Caprihan Jillian Prestopnik Jeffrey Thompson Sasha Hobson David Siegel Gary A. Rosenberg Gary A. Rosenberg |
| author_facet | Erik B. Erhardt John C. Adair John C. Adair Janice E. Knoefel Janice E. Knoefel Arvind Caprihan Jillian Prestopnik Jeffrey Thompson Sasha Hobson David Siegel Gary A. Rosenberg Gary A. Rosenberg |
| author_sort | Erik B. Erhardt |
| collection | DOAJ |
| description | Dual pathology of Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID) commonly are found together at autopsy, but mixed dementia (MX) is difficult to diagnose during life. Biological criteria to diagnose AD have been defined, but are not available for vascular disease. We used the biological criteria for AD and white matter injury based on MRI to diagnose MX. Then we measured multiple biomarkers in CSF and blood with multiplex biomarker kits for proteases, angiogenic factors, and cytokines to explore pathophysiology in each group. Finally, we used machine learning with the Random forest algorithm to select the biomarkers of maximal importance; that analysis identified three proteases, matrix metalloproteinase-10 (MMP-10), MMP-3 and MMP-1; three angiogenic factors, VEGF-C, Tie-2 and PLGF, and three cytokines interleukin-2 (IL-2), IL-6, IL-13. To confirm the clinical importance of the variables, we showed that they correlated with results of neuropsychological testing. |
| first_indexed | 2024-12-17T21:30:11Z |
| format | Article |
| id | doaj.art-638f96ebe2924ec1909fb2251359274e |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-17T21:30:11Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-638f96ebe2924ec1909fb2251359274e2022-12-21T21:31:55ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652021-08-011310.3389/fnagi.2021.717344717344Inflammatory Biomarkers Aid in Diagnosis of DementiaErik B. Erhardt0John C. Adair1John C. Adair2Janice E. Knoefel3Janice E. Knoefel4Arvind Caprihan5Jillian Prestopnik6Jeffrey Thompson7Sasha Hobson8David Siegel9Gary A. Rosenberg10Gary A. Rosenberg11Department of Mathematics and Statistics, University of New Mexico, Albuquerque, NM, United StatesDepartment of Neurology, University of New Mexico, Albuquerque, NM, United StatesCenter for Memory and Aging, Albuquerque, NM, United StatesDepartment of Neurology, University of New Mexico, Albuquerque, NM, United StatesCenter for Memory and Aging, Albuquerque, NM, United StatesThe Mind Research Network, Albuquerque, NM, United StatesCenter for Memory and Aging, Albuquerque, NM, United StatesCenter for Memory and Aging, Albuquerque, NM, United StatesCenter for Memory and Aging, Albuquerque, NM, United StatesDepartment of Anesthesiology, University of New Mexico, Albuquerque, NM, United StatesDepartment of Neurology, University of New Mexico, Albuquerque, NM, United StatesCenter for Memory and Aging, Albuquerque, NM, United StatesDual pathology of Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID) commonly are found together at autopsy, but mixed dementia (MX) is difficult to diagnose during life. Biological criteria to diagnose AD have been defined, but are not available for vascular disease. We used the biological criteria for AD and white matter injury based on MRI to diagnose MX. Then we measured multiple biomarkers in CSF and blood with multiplex biomarker kits for proteases, angiogenic factors, and cytokines to explore pathophysiology in each group. Finally, we used machine learning with the Random forest algorithm to select the biomarkers of maximal importance; that analysis identified three proteases, matrix metalloproteinase-10 (MMP-10), MMP-3 and MMP-1; three angiogenic factors, VEGF-C, Tie-2 and PLGF, and three cytokines interleukin-2 (IL-2), IL-6, IL-13. To confirm the clinical importance of the variables, we showed that they correlated with results of neuropsychological testing.https://www.frontiersin.org/articles/10.3389/fnagi.2021.717344/fullAlzheimer's diseasevascular cognitive impairment and dementiainflammationdiffusion tensor imagingcerebrospinal fluidwhite matter disease |
| spellingShingle | Erik B. Erhardt John C. Adair John C. Adair Janice E. Knoefel Janice E. Knoefel Arvind Caprihan Jillian Prestopnik Jeffrey Thompson Sasha Hobson David Siegel Gary A. Rosenberg Gary A. Rosenberg Inflammatory Biomarkers Aid in Diagnosis of Dementia Frontiers in Aging Neuroscience Alzheimer's disease vascular cognitive impairment and dementia inflammation diffusion tensor imaging cerebrospinal fluid white matter disease |
| title | Inflammatory Biomarkers Aid in Diagnosis of Dementia |
| title_full | Inflammatory Biomarkers Aid in Diagnosis of Dementia |
| title_fullStr | Inflammatory Biomarkers Aid in Diagnosis of Dementia |
| title_full_unstemmed | Inflammatory Biomarkers Aid in Diagnosis of Dementia |
| title_short | Inflammatory Biomarkers Aid in Diagnosis of Dementia |
| title_sort | inflammatory biomarkers aid in diagnosis of dementia |
| topic | Alzheimer's disease vascular cognitive impairment and dementia inflammation diffusion tensor imaging cerebrospinal fluid white matter disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2021.717344/full |
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